1、 KSKSKSKSKSKSKSK KSKSKS KSKSK KSKS KSK KS KS B ISO 10298 KS B ISO 10298:2012 2012 12 17 http:/www.kats.go.krKS B ISO 10298:2012 : ( ) ( ) () ( ) : (http:/www.standard.go.kr) ： ：2002 9 30 ：2012 12 17 2012-0709 ： ： ( 02-509-7274) (http:/www.kats.go.kr). 10 5 , . KS B ISO 10298:2012 i ii 1 1 2 .1 3 .2
2、3.1 .2 3.2 .2 3.3 2 A( ) LC50 .3 B( ) LC50 10 B.1 .10 B.2 10 B.3 .10 B.4 10 B.5 .11 B.6 .11 B.7 .11 C( ) 13 KS B ISO 10298:2012 16 KS B ISO 10298:2012 ii 1995 1 ISO 10298, Determination of toxicity of a gas or gas mixture . . KS B ISO 10298:2012 Determination of toxicity of a gas or gas mixture 1 KS
3、 B ISO 5145 , . . 2 . 2.1 50 LC50 ( , ) (24 ) 1 14 2.2 1 KS B ISO 5145 , . 1： LC50 5 000 ppm(V/V) 2： 200 ppm(V/V) LC505 000 ppm(V/V) 3： LC50200 ppm(V/V) LC50： 1 ppm(V/V) ： 2 GHS(Globally Harmonized System of Classification and Labelling of Chemicals) , . 1： 0 ppm LC50100 ppm(V/V) 2： 100 ppm(V/V) LC5
4、0500 ppm(V/V) 3： 500 ppm(V/V) LC502 500 ppm(V/V) 4： 2 500 ppm(V/V) LC5020 000 ppm(V/V) 3 GHS LC50 4 . A LC50 (3.2.2 ) 2 ( , 1/4 ). 2 B.2 . KS B ISO 10298:2012 2 3 3.1 (3.2) (3.3) . , . , 3.3 . 3.2 3.2.1 OECD TG 40343 . 3.2.2 1 LC50 A . B . 3.3 LC50 . =i iiC5050LC1LC Ci： i LC50i： ppm i LC50 5 000 ppm
5、(V/V) LC50 , 2.2 . 1) . 1) , B.C. Levin et al. Toxicological interactions between carbon monoxide and carbon dioxide. Toxicol, 47, 1987, pp 135 164 KS B ISO 10298:2012 3 A ( ) LC50 A.1 LC50 . A.2 LC50 . A.3 . A.1 LC50 CASaNo. UN No.LC50b/1 hppm(V/V) ( C ) (Ammonia) 7664 41 7 1 005 7 338 1 (Arsine) 7
6、784 42 1 2 188 178 62 (Arsenic pentafluoride) 7784 36 3 3 308 178 (Boron trichloride) 10294 34 5 1 741 2 541 1 (Boron trifluoride) 7637 07 2 1 008 864 44 (Bromine chloride) 13863 41 7 2 901 290 (Carbon monoxide) 630 08 0 1 016 3 760 6 (Carbonyl fluoride ) 353 50 4 2 417 360 5 (Carbonyl sulfide) 463
7、58 1 2 204 1 700 7 (Chlorine) 7782 50 5 1 017 293 1 (Chlorine pentafluoride) 13637 63 3 2 548 122 8 (Chlorine trifluoride) 7790 91 2 1 749 299 8 (Chlorotrifluoroethylene) 79 38 9 1 082 2 000 10 (Chloromethane) 74 87 3 1 063 5 133 54 (Cyanogen) 460 19 5 1 026 350 11 KS B ISO 10298:2012 4 A.1 LC50 ( )
8、 CASaNo. UN No.LC50b/1 hppm(V/V) ( C ) (Cyclopropane) 75 19 4 1 027 220 000 “ ” LCLOc (Cyanogen chloride) 506 77 4 1 589 80 12 (Deuterium chloride) 7698 05 7 1 789 3 120 (Deuterium selenide) 13536 95 3 2 202 51 (Deuterium sulfide) 13536 94 2 1 053 710 (Diborane) 19287 45 7 1 911 80 13 (Dichlorosilan
9、e) 4109 96 0 2 189 314 52 (Dimethylamine) 124 40 3 1 032 5 290 67 (Dinitrogen trioxide) 10544 73 7 2 421 57 NO2 (Ethylene oxide) 75 21 8 1 040 2 900 18 (Fluorine) 7782 41 4 1 045 185 19 (Germane) 7782 65 2 2 192 620 55 (Hexafluoroacetone) 684 16 2 2 420 470 56 (Hydrogen bromide) 10035 10 6 1 048 2 8
10、60 51 (Hydrogen chloride) 7647 01 0 1 050 2 810 45 (Hydrogen iodide) 10034 85 2 2 197 2 860 (Hydrogen selenide) 07783 07 5 2 202 51 57 (Hydrogen sulfide ) 07783 06 4 1 053 712 1 (Hydrogen telluride) 07783 09 7 3 160 51 (Methyl bromide) 74 83 9 1 062 850 23 KS B ISO 10298:2012 5 A.1 LC50 ( ) CASaNo.
11、UN No.LC50b/1 hppm(V/V) ( C ) (Methyl mercaptan) 74 93 1 1 064 1 350 24 (Methyl vinyl ether(inhibited) 107 25 5 1 087 40 00064 000 ppm (Monoethylamine) 75 04 7 1 036 16 000 25 (Monomethylamine) 74 89 5 1 061 7 110 46 (Mustard gas) 4 LCLO 17 (Nitrogen monoxide) 10102 43 9 1 070 115 (Nitrogen dioxide)
12、 10102 44 0 1 067 115 28 (Nitrogen trifluoride) 7783 54 2 2 451 6 700 48 (Nitrosyl chloride) 2696 92 6 1 069 35 LCLO cat 29 (Oxygen difluoride) 7783 41 7 2 190 2.6 8 (Ozone) 10028 15 6 9 30 (Phosgene) 75 44 5 1 076 5 32 (Phosphine) 7803 51 2 2 199 20 64 (Phosphorus pentafluoride)07647 19 0 2 198 261
13、 HF (Phosphorus trifluoride) 7783 55 3 3 308 436 HF (Selenium hexafluoride ) 7783 79 1 2 194 50 39 (Silane) 7803 62 5 2 203 19 000 1 (Silicon tetrafluoride) 7783 61 1 1 859 922 5 (Stibine) 7803 52 3 2 676 178 (Sulfur dioxide) 7446 09 5 1 079 2 520 35 (Sulfur tetrafluoride) 7783 60 0 2 418 40 36 (Sul
14、furyl fluoride) 2699 79 8 2 191 3 020 1 KS B ISO 10298:2012 6 A.1 LC50 ( ) CASaNo. UN No.LC50b/1 hppm(V/V) ( C ) (Tellurium hexafluoride) 7783 80 4 2 195 25 39 (Tetrafluoroethylene) 116 14 3 1 081 2 000 (Trifluoroacetyl chloride) 354 32 5 3 057 10 (Trifluoroethylene) 359 11 5 1 954 2 000 (Trimethyla
15、mine) 75 50 3 1 083 7 000 LCLO 66 (Tungsten hexafluoride) 7783 82 6 2 196 218 HF (Vinyl bromide)(inhibited) 593 60 2 1 085 40 000 (Vinyl chloride)(inhibited) 75 01 4 1 086 150 000 47 (Vinyl fluoride) (inhibited) 75 02 5 1 860 40 000 aCAS Chemical Abstract System b3.2.2 cLCLO (lethal concentration lo
16、w value) KS B ISO 10298:2012 7 A.2 LC50 CASaNo. UN No.LC50b/1 hppm(V/V) ( C ) (Antimony pentafluoride) 7783 70 2 1 732 30 2 (Arsenic trifluoride) 7784 35 2 1 556 178 ( )Bis(trifluoromethyl) peroxide 927 84 4 10 ( ) (Boron tribromide) 10294 33 4 2 692 950 BF3 HBr (Bromine chloride) 13863 41 7 2 901 2
17、90 (Bromine pentafluoride) 7789 30 2 1 745 25 4 (Bromine trifluoride) 7787 71 5 1 746 180 F2 (Bromoacetone) 598 31 2 1 569 260 (Deuterium fluoride) 14333 26 7 1 100 (Dibromodifluoromethane) 1868 53 7 1 941 27 000 LCLO (2- ) Dichloro(2-chlorovinyl) arsine 8 14 (Diethylamine) 109 89 7 1 154 8 000 67 (
18、Diethylzinc) 557 20 0 1 366 non-toxic ( ) 15 (Diphosgene) 503 38 8 1 076 2 ( ) (Ethyldichloroarsine) 598 14 1 1 892 7 LCLO 17 (Heptafluorobutyronitrile) 375 00 8 10 ( ) (Hydrogen cyanide) 74 90 8 1 613 144 59 KS B ISO 10298:2012 8 A.2 LC50 ( ) CASaNo. UN No.LC50b/1 hppm(V/V) ( C ) (Hydrogen fluoride
19、) 7664 39 3 1 052 1 307 CIF5 5 61 (Iodine pentafluoride) 7783 66 6 2 495 120 CIF5 (Methylchlorosilane) 993 00 0 2 534 2 810 HCL 53 (Methyldichloroarsine) 593 89 5 1 556 7 (Methyldichlorosilane) 75 54 7 1 242 1 785 49 (Nickel carbonyl) 13463 39 3 1 259 20 27 (Pentaborane) 19624 22 7 1 380 10 31 (Pent
20、afluorobutyronitrile) None listed 10 (Pentafluoropropionitrile) 422 04 8 10 ( ) (Perchloryl fluoride) 7616 94 6 770 12 (Perfluorobut-2-ene) 360 89 4 12 000 “ ” LCLO 2 (Phenylcarbylamine Chloride) 622 44 6 1 672 5 (Propylene oxide) 75 56 9 1 951 7 140 60 (Silicon tetrachloride) 10026 04 7 1 818 1 312
21、 49 (Tellurium hexafluoride) 7783 80 4 2 195 25 39 (Tetraethyl lead) 78 00 2 1 649 63 37 (Tetrafluorohydrazine)10036 47 2 100 38 KS B ISO 10298:2012 9 A.2 LC50 ( ) CASaNo. UN No.LC50b/1 hppm(V/V) ( C ) (Tetramethyl lead) 75 74 1 800 65 (Thionyl chloride) 7719 09 7 1 836 500 58 (Trichlorosilane) 1002
22、5 78 2 1 295 2 780 50 (Triethylaluminium) 97 93 8 non-toxic ( ) (Triethylborane) 97 94 9 1 400 13 (Trifluoroacetonitrile) 353 85 5 500 ； (taken from) (Trimethylstibine) 178 (Uranium hexafluoride) 7783 81 5 2 978 25 aCAS Chemical Abstract System. b3.2.2 A.3 1 “ ” ISO 10156： 2010 23.5 % . KS B ISO 102
23、98:2012 10 B ( ) LC50 B.1 . , . , . . B.2 W ct . W 50 % . ct . (Haber) . W ct 0.5 . 4 1 , W ct 0.5 LC50 . 1 LC50 2( , 1/4 ) UN Transport Recommendations . , 1 4 LC50 . . 1 , 1 4 , h1h/x . 0.5 . B.3 . . LC50 . , . B.4 LC50 LCLO . LCLO( ) KS B ISO 10298:2012 11 , LC50 . LC50 LCLO . (ALC) , LC50 LCLO .
24、 , LC50 . LC( ) LC50 . B.5 . - . , . B.6 , LD50 . LC50 LD50i.p. . , LD50i.p. 4 . , , 100 mg/kg LD50 1 mg/L 4 LC50 . B.7 LC50 B.1 . 1 (LC50) . , 0.5 (1 ) LC50RAT . MUS( ), , ( ) , , . 1 . LC50 , . LC50 LCLO , , . a) ( ) b) c) d) LD50i.p. KS B ISO 10298:2012 12 LC501LCLO1LC501LC501LC501LC501LC501LC501
25、LCLO1LCLO1LD50LC50LCLO1LCLO1LCLO1LCLO1B.1 KS B ISO 10298:2012 13 C ( ) 1985 “List of serial title word abbreviations”, ISSN 0259000X ISO/ISDS . ISO 10298 . 3, 16, 21, 22 A.1 A.2 . A.1 A.2 44 . 1 Vernot, E.H. et al. Toxicol. Appl. Pharmacol., 42, 1977, pp. 417 423 2 Chekunova, M.P. and Minkina, N.A.
26、Higiena/Sanitariya, 35 (7), 1970, pp. 25 28 3 Levvy, G.A. A study of arsine poisoning. Q.J. Exper. Physiol., 34, 1947, pp. 47 67 4 Toxlit 65； (RTECS)； HSDB 5 Scheel, L.D. et al. Toxicity of carbonyl fluoride, silicon tetrafluoride. Am. Ind： Hyg. Assoc. J., 29, 1968, pp. 41 48 6 Rose, B.S. et al. Acu
27、te hyperbaric toxicity of carbon monoxide. Toxicol. Appl. Pharmacol., 17, 1970, pp. 752 760 7 Ber. Dtsch. Chem. Ges. Abt. 8： Abhandlungen. 76, 299, 43 8 Darmer, K.L. Jr., Haun, C.C. and MacEwen, J.D. Am. Ind. Hyg. Assoc. J., 33, 1972, pp. 661 668 9 Deichmann, W.B. Toxicology of drugs and chemicals, Academic Press, New York, 1969, p. 386 10 Fluor. Chem.
