KS D 2716-2008 Measurement of nanoparticle diameter-Transmission electron microscope《纳米粒子的直径测量技术 透射电子显微镜》.pdf

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1、 KSKSKSKSKSKSKSK KSKSKS KSKSK KSKS KSK KS KS D 2716 KS D 2716:2008 2008 12 26 http:/www.kats.go.krKS D 2716:2008 : ( ) ( ) () ( ) : (http:/www.standard.go.kr) : :2008 12 26 2008-00000951 : : ( 025097274) (http:/www.kats.go.kr). 10 5 , . 0951 KS D 2716:2008 Measurement of nanoparticle diameter Transm

2、ission electron microscope 1 , , . 2 2.1 (nanoparticle) 1 (10 7m 100 nm) 2.2 (vehicle) 2.3 (geometric mean diameter) 2.4 (geometric standard deviation) 2.5 (count median diameter) 3 3.1 3.2 3.3 : 15 mm 3.4 5 KS D 2716:2008 2 3.5 : (0.5 16 L/min) 37 mm MCE(Mixed Cellulose Ester) 3.6 (Transmission Ele

3、ctron Microscope: TEM): , , (energy-dispersive X-ray spectrometer) . 3.7 : 10 200 L 3.8 : 150 200 , . 4 (sampling) 4.1 1 a) 4.1.1 , 0.5 % (carboxy methyl cellulose) . 4.1.2 (voltex mixer) , 30 L (3.8) . 4.2 1 b) 4.2.1 (3.5) , . 4.2.2 . 4.2.3 10 % 2 . 4.2.4 . 4.2.5 , . 4.2.6 . 4.2.7 , . 4.2.8 MCE KS

4、D 2716:2008 3 / 3 mm 3 . 4.2.9 , . 4.2.10 . 4.2.11 5 (3.3) (3.2) . 4.2.12 (3.1) , MCE . 4.2.13 . 30 L a) / 3mm B. b) 1 5 . , , . 6 6.1 . KS D 2716:2008 4 6.2 . 6.3 , . 6.4 . 6.5 500 , . CMD expNdn In CMD : (count median diameter) d : N : 6.6 CMD (Geometric Mean Diameter: GMD) (Geometric Standard Dev

5、iation: GSD) . GMD (aaan21)1/nnnaaa21 GMD : an: n n : GSD nAnigi12lnlnexp GSD : Ai: i g: n : , GSD%50%84dd%16%50dd21%16%84dd GSD : dn %: n % 7 . a) ( , ) KS D 2716:2008 5 b) c) d) e) f) g) X h) ( , ) i) j) k) l) m) KS D 2716:2008 6 KS D 2716:2008 , . 1 , . 1.1 , . 1.2 Ji et al. 2007. Inhal. Toxicol.

6、 19(10): 857 871 & Kim et al. 2008. Inhal. Toxicol. 20(6): 575 583. AC , 92 V 1 000 . MFC(Mass Flow Controller, AERA, FC 7810CD 4V, Japan) . - (evaporation-condensation method) Differential Mobility Analyzer System(DMAS) . 90 , , , . 0.5 % . 300 mg/kg body weight/day 28 , , . . 2 , , . KS D 2716:2008 7 3 3.1 , . 135513 7017 (02)60094114 (02)600948878 http:/ KS D 2716:2008 KSKSKS SKSKS KSKS SKS KS SKS KSKS SKSKS KSKSKS Measurement of nanoparticle diameter Transmission electron microscope ICS 71.040 Korean Agency for Technology and Standards http:/www.kats.go.kr

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