API TR 406-1995 Tert-Amyl Methyl Ether (TAME) - Acute Toxicity to Daphnids (Daphnia Magna) Under Flow- Through Conditions TSCA Guideline Section Mark 797.1300《在流水环境中三戊甲基醚对大型溞急性毒性 T_1.pdf
《API TR 406-1995 Tert-Amyl Methyl Ether (TAME) - Acute Toxicity to Daphnids (Daphnia Magna) Under Flow- Through Conditions TSCA Guideline Section Mark 797.1300《在流水环境中三戊甲基醚对大型溞急性毒性 T_1.pdf》由会员分享,可在线阅读,更多相关《API TR 406-1995 Tert-Amyl Methyl Ether (TAME) - Acute Toxicity to Daphnids (Daphnia Magna) Under Flow- Through Conditions TSCA Guideline Section Mark 797.1300《在流水环境中三戊甲基醚对大型溞急性毒性 T_1.pdf(74页珍藏版)》请在麦多课文档分享上搜索。
1、American Petroleum Institute Tert-Amyl Methyl Ether (TAME)- Acute Toxicity to Daphnids (Daphnia magna) under Flow- through Conditions TSCA Guideline 5797.1 300 FEBRUARY 1995 TOXICOLOGY REPORT NUMBER 406 CAIS ABSTRACT NO. 42-1 51 9 I API TR*40b 95 Se 0732290 0554909 O99 I Ermmwmenta Parnmbrp One of t
2、he most significant long-term trends affecting the future vitality of the petroleum industry is the publics concerns about the environment. Recognizing this trend, API member companies have developed a positive, forward-looking strategy called STEP: Strategies for Todays Environmental Partnership. T
3、his program aims to address public concerns by improving our industrys environmental, health and safety performance; documenting performance improvements; and communicating them to the public. The foundation of STEP is the API Environmental Mission and Guiding Environmental Principles. API ENVIRONME
4、NTAL MISSION AND GUIDING ENVIRONMENTAL PRINCIPLES The members of the American Petroleum Institute are dedicated to continuous efforts to improve the compatibility of our operations with the environment while economically developing energy resources and supplying high quality products and services to
5、 consumers. The members recognize the importance of efficiently meeting societys needs and our responsibility to work with the public, the government, and others to develop and to use natural resources in an environmentally sound manner while protecting the health and safety of our employees and the
6、 public. To meet these responsibilities, API members pledge to manage our businesses according to these principles: 4 9 4 4 9 9 9 9 4 4 9 To recognize and to respond to community concerns about our raw materials, products and operations. To operate our plants and facilities, and to handle our raw ma
7、terials and products in a manner that protects the environment, and the safety and health of our employees and the public. To make safety, health and environmental considerations a priority in our planning, and our development of new products and processes. To advise promptly, appropriate officials,
8、 employees, customers and the public of information on significant industry-related safety, health and environmental hazards, and to recommend protective measures. To counsel customers, transporters and others in the safe use, transportation and disposal of our raw materials, products and waste mate
9、rials. To economically develop and produce natural resources and to conserve those resources by using energy efficiently. To extend knowledge by conducting or supporting research on the safety, health and environmental effects of our raw materials, products, processes and waste materials. To commit
10、to reduce overall emission and waste generation. To work with others to resolve problems created by handling and disposal of hazardous substances from our operations. To participate with government and others in creating responsible laws, regulations and standards to safeguard the community, workpla
11、ce and environment. To promote these principles and practices by sharing experiences and offering assistance to others who produce, handle, use, transport or dispose of similar raw materials, petroleum products and wastes. API TR*4Ob 95 m 0732290 05549110 800 m FOREWORD API PUBLICATIONS NECESSARILY
12、ADDRESS PROBLEMS OF A GENERAL NATURE. WITH RESPECT TO PARTICULAR CIRCUMSTANCES, LOCAL, STATE, AND FEDERAL LAWS AND REGULATIONS SHOULD BE REVIEWED. API IS NOT UNDERTAKING TO MEET THE DUTIES OF EMPLOYERS, MAN- UFACTURERS, OR SUPPLIERS TO WARN AND PROPERLY TRAIN AND EQUIP THEIR EMPLOYEES, AND OTHERS EX
13、POSED, CONCERNING HEALTH AND SAFETY RISKS AND PRECAUTIONS, NOR UNDERTAKING THEIR OBLIGATIONS UNDER LOCAL, STATE, OR FEDERAL LAWS. NOTHING CONTAINED IN ANY API PUBLICATION IS To BE CONSTRUED AS ANY RIGHT, BY IMPLICATION OR OTHERWISE, FOR THE MANUFACTURE, SALE, OR USE OF ANY METHOD, APPARATUS, OR PROD
14、- UCT COVERED BY LEITERS PATENT. NElTHER SHOULD A“G CON- TAINED IN THE PUBLICATION BE CONSTRUED AS INSURING ANYONE AGAINST LIABILITY FOR INFRINGEMENT OF LETERS PATENT. Copyright Q 1995 American Petroleum instimte ACKNOWLEDGMENTS THE FOLLOWING PEOPLE ARE RECOGNIZED FOR THEIR CONTRTBU- TIONS OF TIME A
15、ND EXPERTISE DURING THIS STUDY AND IN THE PREPARATION OF THIS REPORT: - Richard Rhoden, Ph.D., Health and Environmental Sciences Department MBERS OF IlE -COJ .OGY EFFFSTS WORKGROUP Russell D. White, Ph.D., Chainnun, Chevron Research 95% confidence interval calculated by binomial probability. Springb
16、orn Laboratories, Inc. API TR*40b 95 P 0732290 0554923 696 Report No. 92-1 2-4545 Paae 9 of 67 1 .O INTRODUCTION The purpose of this study was to estimate the acute toxicity (EC50) of Tert-Amyl Methyl Ether (TAME) to daphnids (Daphnia magna) under flow-through conditions. The EC50 is defined as the
17、concentration of test material in dilution water which causes immobilization of 50% in the exposed test population after a futed period of time. This value is often used as a relative indicator of potential acute hazards resulting from the release of the test substance into aquatic environments. The
18、 study was initiated on 26 October 1992, the day the Study Director signed the protocol, and was completed on the day the Study Director signed the final report. The experimental phase of the 46-hour definitive toxicity test was conducted from 1 O - 12 December 1992 at Spring born Laboratories, Inc.
19、 (SLI), Environmental Sciences Division, Wareham, Massachusetts. All original raw data and the final report produced for this study are stored at su. 2.0 MATERIALS AND METHODS 2.1 Protocol Procedures used in this acute toxicity study followed those described in the SLI protocol entitled “Protocol fo
20、r Conducting a Flow-Through Acute Toxicity Test with Daphnia magna Following TSCA 5797.1 300“, SLI Protocol #: O91 192/TSCA 797.1 300 DM-FA and Protocol Amendment # 1 dated 15 December 1992 (Appendix I). The methods described in this protocol generally follow the standard procedures described in the
21、 EPNOTS guidelines for testing the effects of chemicals on daphnids and meet the TSCA guidelines as specified in the appropriate Registration Standard. This protocol is intended to meet premanufacture notice (UPMNII) registration requirements. 2.2 Test Material Two samples of Tert-Amyl Methyl Ether
22、(TAME) (CAS # 994-05-8), a clear liquid, were received from Experimental Pathology Labs, Inc., Herndon, Virginia. The first sample, Lot # 0251 462, was received at SLI on 17 August 1992 and was used to prepare exposure solutions during the preliminary exposure, analytical standards during the method
23、 validationhecovery study and to prepare Qualtty Control samples during the definitive exposure. The sample was identified Springborn Laboratories, Inc. API TR*406 95 O732290 0554922 522 W Report No. 92-124545 Page 10 of 67 by Aldrich Chemical Company to contain 98.8% active ingredient A.I. (Certifi
24、cate of Analysis, Appendix Il). The second sample, Lot # 07905Kz, was received at SLI on 2 November 1992 and was used to prepare exposure solutions during the definitive exposures. The sample was identified by Aldrich Chemical Company to contain 98.7% active ingredient A.I. (Certificate of Anaiysis,
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