1、American Petroleum Institute Health and Environmental Sciences Department Tert-Amyl Methyl Ether (TAME)- Acute Toxicity to Mysid Shrimp (Mysidopsis bahia) under Static Renewal Conditions TSCA Guideline 5797.1 930 FEBRUARY 1995 TOXICOLOGY REPORT NUMBER 407 CAIS ABSTRACT NO. 42-1 520 API TR*407 95 W 0
2、732290 0554983 733 W 4- 1. Envrronwl Partmbrp One of the most significant long-term trends affecting the future vitality of the petroleum industry is the publics concerns about the environment. Recognizing this trend, API member companies have developed a positive, forward-looking strategy called ST
3、EP: Strategies for Todays Environmental Partnership. This program aims to address public concerns by improving our industrys environmental, health and safety performance; documenting performance improvements; and communicating them to the public. The foundation of STEP is the API Environmental Missi
4、on and Guiding Environmental Principles. API ENVIRONMENTAL MISSION AND GUIDING ENVIRONMENTAL PRINCIPLES The members of the American Petroleum Institute are dedicated to continuous efforts to improve the compatibility of our operations with the environment while economically developing energy resourc
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6、tecting the health and safety of our employees and the public. To meet these responsibilities, API members pledge to manage our businesses according to these principles: o + 9 o U* 9 9 Q o o 9 To recognize and to respond to community concerns about our raw materials, products and operations. To oper
7、ate our plants and facilities, and to handle our raw materials and products in a manner that protects the environment, and the safety and health of our employees and the public. To make safety, health and environmental considerations a priority in our planning, and our development of new products an
8、d processes. To advise promptly, appropriate officials, employees, customers and the public of information on significant industry-related safety, health and environmental hazards, and to recommend protective measures. To counsel customers, transporters and others in the safe use, transportation and
9、 disposal of our raw materials, products and waste materials. To economically develop and produce natural resources and to conserve those resources by using energy efficiently. To extend knowledge by conducting or supporting research on the safety, health and environmental effects of our raw materia
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11、tions and standards to safeguard the community, workplace and environment. lo promote these principles and practices by sharing experiences and offering assistance to others who produce, handle, use, transport or dispose of similar raw materials, petroleum products and wastes. API TR*407 95 m 073229
12、0 0554984 8T m FOREWORD API PUBLICATIONS NECESSARILY ADDRESS PROBLEMS OF A GENERAL NATURE. WITH RESPECT TO PARTICULAR CIRCUMSTANCES, LOCAL, STATE, AND FEDERAL LAWS AND REGULATIONS SHOULD BE REVIEWED. API IS NOT UNDERTAKING TO MEET THE DUTIES OF EMPLOYERS, MAN- UFACTLTRERS, OR SUPPLIERS TO WARN AND P
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15、70 0554785 706 ACKNOWLEDGMENTS THE FOLLOWING PEOPLE ARE RECOGNIZED FOR THEIR CONTRIBU- TIONS OF TJME AND EXPERTISE DURING THIS STUDY AND IN THE PREPARATION OF THIS REPORT - Richard Rhoden, Ph.D., Health and Environmental Sciences Department ERS OF- EFFECTS WORKGROUP Russell D. White, Ph.D., Chainnun
16、 Chevron Research Good Laboratory Pracfice Standards; Final Rule (40 CFR, Part 792) Federal Register, Part Ill, 48(230): 53922-53944, August 17, 1989. Springborn Laboratories, Inc. API TRa407 95 I 0732290 0555009 BYB = Report No. 945-5269 Page 22 of 73 TABLES Springborn Laboratories, Inc. API TRr40
17、7 95 81 O732290 0555030 56T Report No. 94-5-5269 Page 23 of 73 Table 1. The water quality parameters measured during the 96-hour static renewal exposure of mysld shrimp (Mysidopsis bahia) to TAME. control 1.6 4.0 7.3 15 30 6Q Conti01 1.6 4.0 7.3 15 30 60 8.0 8.0 8.0 8.0 8.0 8.0 8.0 7.6 (1 Ml 7.7 (1
18、w) 7.a (1 07) 7.8 (1 07) (1 cs) 7.8 (1 07) 7.8 (1 07) 7.7 8.0 8.0 8.0 8.0 8.0 1.0 8.0 8.0 7.9 7.9 7.9 8.0 7.9 7.9 7.2 7.0 0 o 6.8 7.1 W) (97) 00 7.1 7.0 0 W) P7) (ss) (SV (ssl en (w) 7.0 7.0 7.1 7.2 7.1 7.0 7.1 7.0 25 22 Measurements at renewal intervals e., 24,48 and i2 hours) are presented as aged
19、flreshiy prepared solutions. Values presented represent the range of daity temperature (B?:*k$in 4lcohol Thermometer) and salinity measured in all test. concentrations and th-e control at the stcrA okervation interval. Continuous temperature monfionng (Fisher Scientific Min/Max thermometer) establ!s
20、hed a temperature range of 24 - 26 OC in the surrounding water bath, throughout the exposure pend. Springborn Laboratories, Inc. API TRa407 95 0732290 05550LL 4Tb Report No. 94-5-5269 Page 24 of 73 Table 2. Concentrations of TAME measured in the replicate (A,B) test solutions during the 96-hour stat
21、ic renewal exposure of mysid shrimp (Mysicfopis bahia). Mean &Hour 96- Hour Nominal Measured Measured Measured Concentratlon Concentrailon Concentrationb Concentration (mg ALL) (mg A1.L) (mg AIA) (mg A.1.L) A B A B Control 0.50 0.50 0.13 0.13 1.6 0.50 1.9 4.3 3.7 4. O 3.9 5.0 5.8 5.4 7.3 9.5 7.7 10
22、10 15 17 17 20 23 30 29 30 39 41 60 65 60 70 66 O - 5.0 (0.8) 9.5 (1.3) 19 (3) 35 (6) 65 (4) QC #1 QC #2 QC #3 i .21 (1 S0)O (30.0) (6w 324 622 1.58 (1 SO) 28.6 (30.0) 58.9 (60.0) * Samples anaiyzed represent the freshiy prepared exposure solutions. Samples anaiyzed represent the aged (24 hour old)
23、exposure sdutions. Mean measured concentrations were calculated using the actual unrounded analytical results and not the rounded (two significant figures) values presented in this table. Standard deviation is shown in parentheses. Exposure solutions were resampled at the 24-hour interval in order t
24、o reevaluate exposure conditions for this treatment level. Resulting measured concentrations were 0.54 and 1.54 mg AI./L on the A and B replicates, respectiveiy. Due to the variability between replicate exposure solutions and sampling intervals, a mean measured concentration will not be calculated for this treatment level. All conclusions will be based on the stated nominal concentration. QC = Quality Control sample. 9 Value in parentheses represents the nominal fortified concentration for the corresponding QC sample. Springborn Laboratories, Inc.
