1、BSI Standards PublicationBS EN 15768:2015Influence of materials onwater intended for humanconsumption GC-MSidentification of waterleachable organic substancesBS EN 15768:2015Incorporating corrigendum September 2015BS EN 15768:2015 BRITISH STANDARDNational forewordThis British Standard is the UK impl
2、ementation of EN 15768:2015. It supersedes BS 6920-4:2001 which is withdrawn.The UK participation in its preparation was entrusted to Technical Committee EH/6, Effects of materials on water quality.A list of organizations represented on this committee can be obtained on request to its secretary.This
3、 publication does not purport to include all the necessary provisions of a contract. Users are responsible for its correct application. The British Standards Institution 2015. Published by BSI Standards Limited 2015ISBN 978 0 580 91430 0ICS 13.060.20; 67.250; 71.040.50Compliance with a British Stand
4、ard cannot confer immunity from legal obligations.This British Standard was published under the authority of the Standards Policy and Strategy Committee on 31 January 2015.Amendments/corrigenda issued since publicationDate Text affected30 September 2015 Correction to supersession details in national
5、 forewordBS EN 15768:2015EUROPEAN STANDARD NORME EUROPENNE EUROPISCHE NORM EN 15768 January 2015 ICS 13.060.20; 67.250; 71.040.50 English Version Influence of materials on water intended for human consumption - GC-MS identification of water leachable organic substances Influence sur leau des matriau
6、x en contact avec leau destine la consommation humaine - Identification par CG-SM de substances organiques lixiviables leau Identifizierung mittels GC-MS von durch Wasser auslaugbaren organischen Substanzen aus Materialien fr den Kontakt mit Trinkwasser This European Standard was approved by CEN on
7、29 November 2014. CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for giving this European Standard the status of a national standard without any alteration. Up-to-date lists and bibliographical references concerning such national standards ma
8、y be obtained on application to the CEN-CENELEC Management Centre or to any CEN member. This European Standard exists in three official versions (English, French, German). A version in any other language made by translation under the responsibility of a CEN member into its own language and notified
9、to the CEN-CENELEC Management Centre has the same status as the official versions. CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, Former Yugoslav Republic of Macedonia, France, Germany, Greece, Hungary, Iceland
10、, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and United Kingdom. EUROPEAN COMMITTEE FOR STANDARDIZATION COMIT EUROPEN DE NORMALISATION EUROPISCHES KOMITEE FR NORMUNG CEN-CENELEC Manageme
11、nt Centre: Avenue Marnix 17, B-1000 Brussels 2015 CEN All rights of exploitation in any form and by any means reserved worldwide for CEN national Members. Ref. No. EN 15768:2015 EBS EN 15768:2015EN 15768:2015 (E) 2 Contents Page Foreword 4 Introduction .5 1 Scope 6 2 Normative references 6 3 Terms a
12、nd definitions .6 4 Principle 9 5 Reagents .9 5.1 General 9 5.2 Required reagents .9 6 Apparatus 13 7 Storage of migration waters, procedural blanks and laboratory blanks 14 8 Method of analysis 14 8.1 Extraction procedure 14 8.2 GC-MS analysis . 15 8.2.1 Safety precautions 15 8.2.2 Mass spectromete
13、r operating parameters . 15 8.2.3 Setting up the mass spectrometer and data system 15 8.2.4 Initial tuning and mass calibration of the mass spectrometer 15 8.3 Setting up the GC-MS system . 15 8.4 GC-MS operating conditions for analysis of solvent extracts . 16 8.5 Production of required outputs fro
14、m the GC-MS data system 17 9 Quality assurance (QA) and quality control (QC) procedures . 17 9.1 The mass calibration of the mass spectrometer . 17 9.2 The performance of the GC-MS system . 17 9.3 The performance of the method 17 9.4 Performance of the analyst 18 9.5 Uncertainty of the method . 18 1
15、0 Expression of results . 18 10.1 Semi-quantitative estimation of concentrations of substances detected 18 10.2 Identification of substances detected 19 10.3 Reporting of results 19 11 Test report . 20 11.1 General . 20 11.2 Test results 21 Annex A (normative) Additional procedural details . 23 A.1
16、Checking suitability of apparatus used for concentrating solvent extracts 23 A.2 Procedure for calculation of recoveries of internal standards 23 A.3 Standard solutions for checking GC column performance . 24 Annex B (informative) Outline of general approach for identification of substances detected
17、. 25 B.1 General approach - Introduction . 25 B.2 GC-MS Test Solution 25 BS EN 15768:2015EN 15768:2015 (E) 3 B.3 Typical Leachate 26 B.4 Identifying substances 26 B.5 Overloading 27 Annex C (informative) Guidance on the interpretation of results 28 C.1 Introduction 28 C.2 Initial assessment of test
18、report 28 C.3 Assessment of results of analysis 28 Annex D (informative) Guidance on the identification of substances . 30 D.1 A suggested strategy to assist in identifying substances in extracted leachates . 30 D.2 Resolution of co-eluting peaks 30 D.3 Proceeding when background subtraction does no
19、t help 31 D.4 Tentatively identifying a substance using boiling points and retention indices 31 D.5 Library search results and identifying “unknown” substances . 32 D.6 Interpretation of the mass spectrum . 32 D.7 Reporting confidence in a substance identification 33 D.8 How to report alternative id
20、entifications and when this is appropriate 33 D.9 What to do if library search fails to assign a reasonable identification 34 BS EN 15768:2015EN 15768:2015 (E) 2 Contents Page Foreword 4 Introduction .5 1 Scope 6 2 Normative references 6 3 Terms and definitions .6 4 Principle 9 5 Reagents .9 5.1 Gen
21、eral 9 5.2 Required reagents .9 6 Apparatus 13 7 Storage of migration waters, procedural blanks and laboratory blanks 14 8 Method of analysis 14 8.1 Extraction procedure 14 8.2 GC-MS analysis . 15 8.2.1 Safety precautions 15 8.2.2 Mass spectrometer operating parameters . 15 8.2.3 Setting up the mass
22、 spectrometer and data system 15 8.2.4 Initial tuning and mass calibration of the mass spectrometer 15 8.3 Setting up the GC-MS system . 15 8.4 GC-MS operating conditions for analysis of solvent extracts . 16 8.5 Production of required outputs from the GC-MS data system 17 9 Quality assurance (QA) a
23、nd quality control (QC) procedures . 17 9.1 The mass calibration of the mass spectrometer . 17 9.2 The performance of the GC-MS system . 17 9.3 The performance of the method 17 9.4 Performance of the analyst 18 9.5 Uncertainty of the method . 18 10 Expression of results . 18 10.1 Semi-quantitative e
24、stimation of concentrations of substances detected 18 10.2 Identification of substances detected 19 10.3 Reporting of results 19 11 Test report . 20 11.1 General . 20 11.2 Test results 21 Annex A (normative) Additional procedural details . 23 A.1 Checking suitability of apparatus used for concentrat
25、ing solvent extracts 23 A.2 Procedure for calculation of recoveries of internal standards 23 A.3 Standard solutions for checking GC column performance . 24 Annex B (informative) Outline of general approach for identification of substances detected. 25 B.1 General approach - Introduction . 25 B.2 GC-
26、MS Test Solution 25 BS EN 15768:2015EN 15768:2015 (E) 3 B.3 Typical Leachate 26 B.4 Identifying substances 26 B.5 Overloading 27 Annex C (informative) Guidance on the interpretation of results 28 C.1 Introduction 28 C.2 Initial assessment of test report 28 C.3 Assessment of results of analysis 28 An
27、nex D (informative) Guidance on the identification of substances . 30 D.1 A suggested strategy to assist in identifying substances in extracted leachates . 30 D.2 Resolution of co-eluting peaks 30 D.3 Proceeding when background subtraction does not help 31 D.4 Tentatively identifying a substance usi
28、ng boiling points and retention indices 31 D.5 Library search results and identifying “unknown” substances . 32 D.6 Interpretation of the mass spectrum . 32 D.7 Reporting confidence in a substance identification 33 D.8 How to report alternative identifications and when this is appropriate 33 D.9 Wha
29、t to do if library search fails to assign a reasonable identification 34 BS EN 15768:2015EN 15768:2015 (E) 4 Foreword This document (EN 15768:2015) has been prepared by Technical Committee CEN/TC 164 “Water supply”, the secretariat of which is held by AFNOR. This European Standard shall be given the
30、 status of a national standard, either by publication of an identical text or by endorsement, at the latest by July 2015 and conflicting national standards shall be withdrawn at the latest by July 2015. Attention is drawn to the possibility that some of the elements of this document may be the subje
31、ct of patent rights. CEN and/or CENELEC shall not be held responsible for identifying any or all such patent rights. This document has been prepared under a mandate given to CEN by the European Commission and the European Free Trade Association. This document has been prepared on the basis of co-nor
32、mative research project EVK1-CT 2000-00052 and work funded by DG Enterprise and Industry (Grant Agreement S12.403892). This document describes methods of identification only, and should not be used or quoted as a specification. References to this document should indicate that the methods of identifi
33、cation used are in accordance with EN 15678:2015. According to the CEN-CENELEC Internal Regulations, the national standards organizations of the following countries are bound to implement this European Standard: Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland,
34、Former Yugoslav Republic of Macedonia, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and the United Kingdom. BS EN 15768:2015EN 15768:2015 (E) 5 I
35、ntroduction Organic substances that migrate from products containing such substances have, when used in contact with water intended for human consumption, the potential to cause health concerns for consumers. The potential health effects of these chemicals are assessed in three stages as follows: a)
36、 preparation of migration waters by exposing a portion of the material to water under controlled conditions; b) analysis of the migration waters; c) assessment of the identities and concentrations of the substance detected. The analysis of organic substances present in migration waters can involve t
37、wo different types of analytical methods as follows: d) a screening method, which allows a variety of substances to be detected and a semi-quantitative assessment to be made of their concentrations; e) accurate quantitative methods for the determination of specific target substances known to be pres
38、ent in the chemical formulations of the materials. This standard describes the analytical procedures based upon gas chromatography and mass spectrometry (GC-MS) used to screen migration waters for organic substances derived from finished products such as pipes, protective coatings, membranes, etc. T
39、his method is suitable for migration waters from all products that can potentially release organic chemicals into water when they are used in contact with water intended for human consumption, and which are the subject of an application for approval by the national regulatory body. It may be one of
40、several methods that form part of the overall approval process. The method may also be used as part of an approval audit process. The method does not provide accurate quantitative results and other analytical methods are recommended for accurate quantitative determination of specific target substanc
41、es. BS EN 15768:2015EN 15768:2015 (E) 4 Foreword This document (EN 15768:2015) has been prepared by Technical Committee CEN/TC 164 “Water supply”, the secretariat of which is held by AFNOR. This European Standard shall be given the status of a national standard, either by publication of an identical
42、 text or by endorsement, at the latest by July 2015 and conflicting national standards shall be withdrawn at the latest by July 2015. Attention is drawn to the possibility that some of the elements of this document may be the subject of patent rights. CEN and/or CENELEC shall not be held responsible
43、 for identifying any or all such patent rights. This document has been prepared under a mandate given to CEN by the European Commission and the European Free Trade Association. This document has been prepared on the basis of co-normative research project EVK1-CT 2000-00052 and work funded by DG Ente
44、rprise and Industry (Grant Agreement S12.403892). This document describes methods of identification only, and should not be used or quoted as a specification. References to this document should indicate that the methods of identification used are in accordance with EN 15678:2015. According to the CE
45、N-CENELEC Internal Regulations, the national standards organizations of the following countries are bound to implement this European Standard: Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, Former Yugoslav Republic of Macedonia, France, Germany, Greece, Hunga
46、ry, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and the United Kingdom. BS EN 15768:2015EN 15768:2015 (E) 5 Introduction Organic substances that migrate from products containing
47、such substances have, when used in contact with water intended for human consumption, the potential to cause health concerns for consumers. The potential health effects of these chemicals are assessed in three stages as follows: a) preparation of migration waters by exposing a portion of the materia
48、l to water under controlled conditions; b) analysis of the migration waters; c) assessment of the identities and concentrations of the substance detected. The analysis of organic substances present in migration waters can involve two different types of analytical methods as follows: d) a screening m
49、ethod, which allows a variety of substances to be detected and a semi-quantitative assessment to be made of their concentrations; e) accurate quantitative methods for the determination of specific target substances known to be present in the chemical formulations of the materials. This standard describes the analytical procedures based upon gas chromatography and mass spectrometry (GC-MS) used to screen migration waters for organic substances derived from finished products such as pipes, protective coatings, membranes, etc. This method is suitable for migration waters
