1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32373 2013 (OECD, Test 402:1987, IDT) 323732013 II , 1.092 . 1.22009 . , . , , , 1 ( ), - , , ( ) 2 3 , ( 18 2013 . 60) : ( 3166) 004 97 ( 3166) 004 97 AM BY KG MD RU TJ - 4 OECD Test 402 Acute Dermal Toxicity ( 402 ). (
2、en). (IDT) 5 22 2013 . 797- 323732013 1 2014 . 6 , . () . , , 2014 , 323732013 III , , . . , . 323732013 1 Testing of chemicals of health hazard Test for Acute Dermal Toxicity 20140801 1 . . : ; ; in vivo in vitro; ; . , . 2 : 2.1 (Dosage): , , (). 2.2 (Dose-response): . 2.3 (Dose-effect): . 2.4 (Ac
3、ute dermal toxicity): , . 2.5 DL50/LD50( , ): , 50 % , . DL50/LD50 (/). 3 , . . , , , . , , . , , () . 4 4.1 ( ) 323732013 2 . , . 24 . , , . 10 % . , , , , , . . . 4.2 4.2.1 , . , . : 200300 ; 23 ; 350450 . , , . , . . . . , , , . . (223) , (203) , 30 % 70 %, 12 , 12 . . 4.2.2 , . , , DL50/LD50. 4.
4、2.3 () () 2000 / . . . 4.2.4 14 . , , ; . , , . 4.3 . , 10 % . , , , . , , , 24 . , , , , . , , . 323732013 3 . , , . , , . , , . , , , , , , . , , , , , . . , , . . . . , 24 , . , ( ) . . , . 5 , , , , , , . , . , . , , . DL50/LD50 . DL50/LD50 . DL50/LD50 . , DL50/LD50. , , , , , , , . 6 , , : -, , , , .; - , ( ); - , , ; - , ; - (. ,
