GOST 32378-2013 Testing of chemicals of human hazard One-generation reproduction toxicity study《人类危险化学品测试 一代生殖毒性研究》.pdf

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1、 , ( )INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION(ISC) 32378 2013 (OECD, Test 415:2007, IDT 2014 323782013 II, 1.0 92 . 1.2 2009 . , - . , , -, 1 - - ( ); - , , ( )2 3 , (- 60- 18 2013 .) : ( 3166) 004 97 ( 3166) 004 97 AMBYKGMDRUTJ -4 OECD Test 415:2007 One-Gen-eration Repro

2、du tion To i it tud ( ). (en). (IDT)5 22 2013 . 803- 32378-2013 - 1 2014 .6 - , - . ( ) - . , , 2014 -, 323782013 III . - . , , , , . 32378 2013 IV1 323782013 2014 08 011 , , , , , , . , . , , , , .2 :2.1 (Dose): . (, ), (, /), (ppm).2.2 (Dosage): , , - .2.3 (Maternal toxicity): , ( ), ( -).2.4 (Rep

3、roductive toxicity): - / .3 . , , ( 56 70 ) -. (P) , , . . - . . Testing of chemicals of human hazardOne-generation reproduction toxicity study 32378 2013 24 4.1 . . - . . . - , . .4.2 -, , ;- ;- () ;- ;- / ( );- ( ).4.3 4.3.1 . , . . - , , , / . 4.3.2 -, 20 , . - , -, F1 .4.3.3 (223) ” (183) ” . ,

4、 30 % 70 %, - , 50 % 60 %. 12 , 12 . . , . - , - .4.4 . - , - . - , . , , , - , . , ; - . , . , - 0- 5- . 323782013 34.5 , 1000 / , . - - , .5. 5.1 (P) 5 9 , - , . - 10 ( 8 ). , - , . (P) - . () , - F1. , , , .5.2 1:1 ( ) 1:2 ( ). 1:1 . . . . , - , , , .5.3 . , . 4- . - . , / , , , . 8 .5.4 . , , , . - . ( , ) . 323782013 4 , . . , (0) - . , , . 4- - . , , 4- 7- , , . , .5.5 5.5.1 , . .5.5.2 , , , , , , , , , () ( ) (). , , , . ,

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