GOST 32379-2013 Testing of chemicals of human hazard Reproduction developmental toxicity screening test《人类危险化学品测试 生殖和发育毒性筛选试验》.pdf

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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32379 2013 / ( ) (OECD, Test 421:2010, IDT) 323792013 II , 1.092 . 1.22009 . , . , , , 1 ( ); - , , ( ) 2 3 , ( 18 2013 . 60-) : ( 3166) 004 97 ( 3166) 004 97 AM BY KG MD RU TJ - 4 OECD Test 421 Reproduction/Developmenta

2、l Toxicity Screening Test ( 421 / ). (en). (IDT) 5 22 2013 . 807- 323792013 1 2014 . 6 , . () . , , 2014 , II 323792013 III . . , , , , , . , . 323792013 1 / ( ) Testing of chemicals of human hazard Reproduction/developmental toxicity screening test 20140801 1 / , , . , ; / . . , , . , , , . , . , ,

3、 , (NOAEL). , / , . . . 2 : 2.1 (Evident toxicity): , , . , . 2.2 (Dose): . (, ), (, /), (ppm). 2.3 (Dosage): , , . 2.4 (Maternal toxicity): , ( ), ( ). 2.5 (Impairment of fertility): . 2.6 (Reproduction toxicity): / . 2.7 (Developmental toxicity): , 323792013 2 -, -, . 2.8 NOAEL (): , . 3 . , , , (

4、 , ). , . . / , , , , . . ( ), , , , , . 54 , ( 14 , 14 , 22 , 4 ). . , , . , . 4 4.1 . , . . , . , , , / . 20 % , , . 4.2 (223) . 30 % 70 % ( ), 50 % 60 %. 12 , 12 . . , . ; . . . 4.3 . , . 5 . 4.4 , . , 323792013 3 , , . , . , , /, (, ) . , , . . 5 5.1 10 . , 8 , . , , , , . 5.2 . . , . , . . , . , , (NOAEL), . , (, 10) . 5.3 1000 / , , , , . , . , ,

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