1、 32380 2013 III - . , . 32380 2013 22.10 / (Malformation/Major Abnormality): , ( ), , , -.2.11 (Early resorption): -/.2.12 (Resorption): , , - .2.13 () (Developmental toxicology): , , . : 1) , 2) , 3) , 4) . 2.14 ( ) (Foetotoxicity): - , , / .2.15 (Embryo): , - .2.16 (Embryotoxicity): , -, / .2.17 N
2、OAEL (): , - .3 , , . ( 5 15 , 6 18 ), , , -, . , .4 4.1 . , - , - . , . .4.2 (223) ” (183) ” . 30 % 70 %, - , 50 60 %. 12 , 12 . . , . - , .4.3 , - 5 . , , , . - 32380 2013 3 . - . , ( ) . 0 , / ; 0, , , . . , , , . - . - , . 5. 5.1 20 . , 16 , . , - 10 %, .5.2 : , , - / ; , ; . - .5.3 , ( 5 ) , . - , , , - . , (). , , : , , . , , . . -. - , - / ( ), . , . - - . , - , (NOAEL), , . / , , - , - ( 10 ) . , NOAEL , , - , . , - 32380 2013 4 . -. . , - . . () - . , , ( ).5.4 1000
