GOST 32435-2013 Testing of chemicals of health hazard Skin absorption In vitro method《健康危险化学品测试 皮肤吸收 体外法》.pdf

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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32435 2013 - : in vitro (OECD, Test 428:2004, IDT) 2014 324352013 , 1.092 . 1.22009 . , . , , , 1 ( ), - , , ( ) 2 3 , ( 44-2013 14 2013 .) : ( 3166) 004 97 ( 3166) 004 97 AM KG MD RU TJ - 4 OECD Test 428:2004 Skin Absor

2、ption: In Vitro Method (- : in vitro). (en). (IDT) 5 22 2013 . 774- 324352013 1 2014 . 6 , . () . , . , 2014 , II 32435-2013 , . in vivo 32371 . , , 1. : in vivo in vitro. in vitro, 2. 2 : in vivo in vitro. in vitro , , . , . in vitro . in vitro . - . , . , . III 324352013 - : in vivo Testing of che

3、micals of health hazard Skin absorption: In vitro method 20140801 1 - in vitro. 2 : 2.1 : , . , . 2.2 (Unabsorbed dose): , , , . 2.3 (in vitro) (Absorbed dose): , . 2.4 (in vitro) (The absorbable dose): , . , 1 , . (), () . , , , , . 3 , , , (). , . / . . , , . , 2, . , , , , , . (, ) , . 1 32435201

4、3 , , . ( , ) (, , ). 4 4.1 , ( 1). ( ); ; , 2,54 2; ; ; ; / (321) ; , ; / ; , . 1 in vitro , , . , . . . 2 32435-2013 4.2 , , , . . , . . . . . 4.3 . , , . , ( , ), ( 200 400 ), . , ( 1 ) , . , . , , . 4.4 , . , , . 24 , , , . , , . 4.5 (, , , , ) ( ), . . 4.6 . . 4.7 , , 1 5 /2 10 /2 . , . , , , . 4.8 (, , - ) . , (321) . . 30 % 70 %. 3 324352013 4.9 ( ). , . . 24 . 24 , 24 . , , .

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