GOST 32542-2013 Testing of chemicals of health hazard Acute inhalation toxicity《对危害健康的化学品的测定 急性吸入毒性》.pdf

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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32542 2013 . (OECD, Test No403:2008, IDT) 325422013 II , 1.0 92 . 1.22009 . , . , , , 1 ( ), - , , ( ) 2 3 , ( 14 2013 . 442013) : ( 3166) 004 97 ( 3166) 004 97 AM BY KG MD RU TJ - 4 OECD Test 403:2008 Acute Inhalation T

2、oxicity ( ). (en). (IDT) 5 22 2013 . 796- 325422013 1 2014. 6 , . () . , , 2014 , 325422013 III . . , 4, 5. : CL50 /LC50 ( Ct) 1. - , (CL50 /LC50), (CL01/LC01), . Ct , , , ( (AEGL), (ERPG) (AETL), . , C(GHS) . 325422013 1 Testing of chemicals of health hazard Acute Inhalation Toxicity 20140801 1 . 2

3、 : : 2. : , , . 0.001 100 m. : , , , . ( ): , , : , . , , . : , , . : (, /., /3) (., , ). : , 24 . 4 . : , , , , . . , (. ). : , . ( ): , , . /GHS, 20 000 ppm , 20 / 5 / . : , , . , , , 0,5 . 325422013 2 : , . , , , , 2. (MMAD): . , . , , 50 % . MMAD 1 4 m. /GHS ( ): , , , , , . ( ), ( ) () ( ) (IOM

4、C). CL50/LC50( ): , 50 % , . CL50 /LC50 (/, /3) (, ). (, CL50 /LC50). 3 3.1 . , , , ; in vivo in vitro; ; , (Q)SAR . / , . / , , in vitro, pH, . , , , , . ; . (CL50/LC50, CL01/LC01) , . . , ( ) ; 24 ( , 4 ). (Ct), , ( ) . 325422013 3 , , , ( ). , . , . 3.2 3.2.1 . . . 3.2.2 . 8 12 , 20 % , , . , . , . . 3.2.3 , , (223) , 30 70 %. , , . ( , ) , . ,

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