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GOST 32637-2014 OECD guidelines for the testing of chemicals Repeated dose 90-day oral toxicity study in rodents《化学品试验OECD指南 对啮齿类动物重复90天口服剂量的毒性研究》.pdf

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1、 : 90-(OECD, Test 408:1998, IDT) , ()INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION(ISC)326372014, - 1.092 . - 1.22009 . , . , , -, 1 - , , - ( ); 339 , - , 52 (-)3 , (- 30 2014 . 67-) : ( 3166) 00497 ( 3166) 00497 AZAMBYKZKGMDRUTJTMUZUA - 4 6 2014 . 1273- 326372014 - 1 2015 .5

2、OECD Test 408:1998 RepeatedDose 90-Day Oral Toxicity Study in Rodents ( -: 90-). (en). (IDT)6 - , - . () - . , , 2015 -, II 326372014 .IV1 12 13 .14 24.1 .24.1.1 .24.1.2 .24.1.3 24.2 .24.3 .24.3.1 24.3.2 24.3.3 .34.3.4 34.4 34.4.1 / 44.4.2 .44.5 .54.5.1 54.5.2 .55 .65.1 .65.2 .6 .7III 326372014 . 40

3、8 1981 . - , - , . 408 - , c 23 1995 .IV 326372014 :90-Testing methods on impact of chemical production on a human body.Repeated dose 90-day oral toxicity study in rodents 201506011 , - - 28- . 90- , -, . , - , - , . - . . - , , , .2 :2.1 (Dose): . (,), (, /), (ppm).2.2 (Dosage): , , .2.3 NOAEL (no-

4、observed-adverse-effect level): , , - .3 , , , 90 . - . , , - ; - .1 326372014 4 4.1 4.1.1 , , , . - . -. , , , . c177 20 % . , - , .4.1.2 22 C (c177 3C).,30%,70%,- , 50 %60 %. , 12 , 12 - . . . - 3, 4, 5.4.1.3 , - 5 , - . , , , , / -. . , - . .4.2 . / . . , , -/, / (, ), . , , - . .4.3 4.3.1 20 (10 10 ). , - , . , - ( ) , , - . .4.3.2 - , , (. 4.3.3). - / , , -2 326372014. , - , , . - (NOAEL) . - , (, 610) . , -, . , -. , . , , , . , : , , ; - , , , .4.3.3 , 1000 / /, , , - , , - , . -, .4.3.4 90 . . - , , . , , . 1 /100 , -, 2 /100 . - ,

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