GOST 32642-2014 Guidelines for the testing of chemicals Repeated dose dermal toxicity 21 28-day study《化学品试验指南 重复剂量经皮毒性 为期21 28天的研究》.pdf

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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32642 2014 / . 28/21- (OECD, Test 410:1981, IDT) 326422014 II , 1.092 . 1.22009 . , , . , , 1 ( ); - , , ( ); 339 , 2 3 , ( 28 2014 . 65-) : ( 3166) 004 97 ( 3166) 004 97 AZ AM BY KZ KG MD RU TJ TM UZ UA - 4 OECD Test 41

2、0: 1981 Repeated Dose Dermal Toxicity: 21/28-day Study ( 410: 1981 : 21/28- ). (en). (IDT) 5 22 2014 . 1163- 326422014 1 2015 . 6 326422014 III , . () . , , 2015 , 326422014 IV . , . 21- 28- , . , . 326422014 1 / . 28/21- Guidelines for the testing of chemicals. Repeated Dose Dermal Toxicity: 21/28-

3、day Study 20150601 1 21/28 . 2 : 2.1 (Dose): , . (, ) (, /). 2.2 (Cumulative toxicity): , . 2.3 NOAEL (No-effect level/No-toxic-effect level/No-adverse-effect level): : , . 3 , 21/28 . : - : ; - ; - () ; - ; - ph ( ); - , , ; - / . . , , , . 4 4.1 , , . . . 326422014 2 , 24 . . , , , , . 10 % . , .

4、 , , . . . 4.2 4.2.1 : , . , . : - 200300 ; - 2,03,0 ; - 350450 . , . 4.2.2 , , 10 ( ) . . , , . , 10 ( ) 21/28 14 . 4.2.3 . (223) (203) C 30 % 70 % . : 12 12 . . 4.3 4.3.1 , , , . , , . , , . . , , . , (-) (-) . , , . , , . , , . , . 4.3.2 , 1000 / ( ), , , , , . 326422014 34.3.3 , . , , , , , . 4.4 21/28 . , , . , , 14 , . , 10 % . , . , . , , , , , . , , . , : , . : , , , , , , . . , , , . . . 4.5 : - , , , , , , , , , . - . , . . , , , , , ( ). - 1, 2, , -, , , , . ,

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