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GOST 32647-2014 OECD guidelines for the testing of chemicals Combined chronic toxicity carcinogenicity studies《化学品试验OECD指南 综合慢性毒性 致癌研究》.pdf

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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32647 2014 (OECD, Test 453:2009, IDT) 326472014 II , 1.092 . 1.22009 . , , . , , 1 - , , ( ); 339 , 2 3 , ( 28 2014 . 65-) : ( 3166) 004 97 ( 3166) 004 97 AZ AM BY KZ KG MD RU TJ TM UZ UA - 4 OECD Test 453:2009 Combined

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3、oxicityCarcinogenicity Studies 20150601 1 , . , , (. S1B ). , , , . , , , , TG 409, 90- - 7, 116 8. / : , . , . 116 8. , . , , / , . , , , / ( , .) 8, 9 8. TG 412 10 TG 413 11, 9, , . TG 410 12 , . / , . , , - . , , , . . /, , : 326472014 2 - , , , ; - ; - ; - - , - -; - (NOAEL) (BMD); - , - ; - 3,

4、8, 13, 14, 15, 16. 2 : ( . 34 35 ). , . , , , 12- , (. 34). , , . , , 3 6 . (. . 20). . . , , . . , , , . 3, 8, 13, 14, 15, 16, , , , . 116 8. , , : , - ; ; invitro invivo , ; ; (Q)SAR / , ; ( , , ) , . 28- 90- . . 17, 18, 19, 20. , , , . : , , . 326472014 3 116 8 , 35 21. , , , , , 22, 62, . , “ , , , . , , . , . , , , , , -. 116 8, 23, 24. (. 6). . . (TG 452) (TG 451), . , ,

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