1、 KSKSKSKSKSKSKSK KSKSKS KSKSK KSKS KSK KS KS J 0050 3 3：KS J 0050 3:2010 2010 12 24 http:/www.kats.go.krKS J 0050 3:2010 : ( ) ( ) KT&G ( ) : (http:/www.standard.go.kr) ： ：2005 3 31 ：2010 12 24 2010-0626 ： ： ( 02-509-7294) (http:/www.kats.go.kr). 10 5 , . KS J 0050 3:2010 i ii iii 1 1 2 1 3 .1 4 .2
2、5 .3 A( ) .5 A.1 1 5 A.2 2 5 A.3 3 5 A.4 4 6 A.5 7 B( ) (OIE list) 8 B.1 List A 8 B.2 List B 8 9 KS J 0050 3:2010 ii . KS J 0050 3： 2005 . . , , . , , . KS J 0050 3:2010 iii , . KS J 0050 3:2010 3： Bioindustry Pathogen list and its biosafety class Part 3： Fungi 1 , . , . 2 . . ( ) . KS J 0001, 3 . K
3、S J 0001 . 3.1 (pathogen) . , , ( , , , ), (fungi), , (protozoa) 6 . , . 3.2 (opportunistic infection) . . ( , ), ( , ), , , , . KS J 0050 3:2010 2 3.3 (genetically modified microorganisms) , , . (Cartagena Protocol on Biosafety under the Convention on Biological Diversity) . 3.4 (modern biotechnolo
4、gy) DNA (family) . 1 (microinjection), (macroinjection), (chemoporation), (electroporation), (microencapsulation), (liposome fusion) . 2 (protoplast fusion) (hybridization) . 4 . a) 1 (class 1) b) 2 (class 2) c) 3 (class 3) , d) 4 (class 4) , 1 , , . , . , . 2 . a) (Korea Center for Disease Control
5、and Prevention)3b) (National Veterinary Research and Quarantine Service)4c) (National Fisheries Research and Development Institute)5d) (World Health Organization)6e) (The Office International des Epizooties, OIE)7f) EU (European Economic Community Directive)8 g) (National Institute of Infectious Dis
6、eases)9h) (National Institute of Animal Health)10i) (National Institutes of Health： NIH)11KS J 0050 3:2010 3 j) / (Centers for Disease Control and Prevention/ National Institutes of Health： CDC/NIH)12 k) (Animal and Plant Health Inspection Service： APHIS)13l) (American Biological Safety Association)
7、14m) (Public Health Agency of Canada)15n) DSM(Deutsche Sammlung von Mikroorganismen GmbH)165 1 Absidia corymbifera 2 2 Acremonium spp. 2 3 Arthroferma(Trichophyton) simii(some strains) 2 4 Aspergillus flavus 2 5 Aspergillus fumigatus 2 6 Aspergilus parasiticus 2 7 Aspergilus spp. 2 8 Blastomyces(Aje
8、llomyces) dermatitidis 2 9 Candida albicans 2 10 Candida spp. 2 11 Cladosporium bantianum 2 12 Cladosporium carrionii 2 13 Cladosporium(Xylohypha) trichoides 2 14 Coccidioides immitis 3 15 Cryptococcus neoformans 2 16 Cryptococcus neoformans var gattii 2 18 Cryptococcus neoformans var neoformans 2 2
9、0 Dactylaria(Ochroconis) gallopava 2 21 Dermatophilus congolensis 2 22 Emmonsia parva 2 23 Emmonsia parva var crescens 2 24 Epidermophyton floccosum 2 25 Epidermophyton spp. 2 26 Exophiala(Wangiella) dermatitidis 2 27 Fonsecaea compacta 2 28 Fonsecaea pedrosol 2 29 Fusarium moniliform 2 30 Fusarium
10、solani 2 31 Histoplasma capsulatum 3 32 Histoplasma capsulatum var capsulatum 3 33 Histoplasma capsulatum var duboisii 3 34 Histoplasma farcinimosum 3 KS J 0050 3:2010 4 35 Histoplasma spp. 3 36 Madurella grisea 2 37 Madurella mycetomati 2 38 Microsporum spp. 2 39 Neotestudina rosatii 2 40 Paecilomy
11、ces spp. 2 41 Paracoccidioides brasiliensis 2 42 Penicillium marneffei 2 43 Pneumocystis carinii 2 44 Rhizopus cohnii 2 45 Rhizopus microspous 2 46 Sporothrix schenckii 2 47 Trichophyton rubrum 2 48 Trichophyton spp. 2 KS J 0050 3:2010 5 A ( ) . A.1 1 Vibrio cholerae O1, O139 Yersinia pestis Salmone
12、lla Typhi(Salmonella enterica subsp. enterica serovar Typhi) Salmonella Paratyphi A, Paratyphi B, Paratyphi C(Salmonella enterica subsp. enterica serovar Paratyphi A, Salmonella enterica subsp. enterica serovar Paratyphi B, Salmonella enterica subsp. enterica serovar Paratyphi C) Shigella dysenteria
13、e, Shigella flexneri, Shigella boydii, Shigella sonnei Enterohaemorrhagic Escherichia coli A.2 2 Corynebacterium diphtheriae Bordetella pertussis Clostridium tetani Measles virusMorbillivirus sp.( ) ssRNA Mumps virusRubulavirus sp.( ) ssRNA Rubella virusRubivirus sp.( ) ssRNA Poliovirus(type 1, 2, 3
14、)Enterovirus sp.( ) ssRNA B Hepatitis B virus Japanese encephalitis virusFlavivirus sp.( ) ssRNA A.3 3 KS J 0050 3:2010 6 Plasmodium vivax, P. falciparum, P. malariae, P. ovale Mycobacterium tuberculosis Mycobacteriu leprae Treponema pallidum Neisseria gonorrhoeae Chlamydia trachomatis Haemophilus d
15、ucreyi Herpes simplex virus(HSV)(Simplexvirus spp.) Human papillomavirus(HPV)(Papillomavirus spp.) Streptococcus pyogenes Neisseria meningitidi Legionella spp. Vibrio vulnificus Rickettsia prowazekii Rickettsia typhi(R. mooseri) Orientia tsutsugamushi Leptospira spp. Brucella spp. Bacillus anthracis
16、 Rabies virusLyssavirus sp.( ) ssRNA ( ) HantavirusesHantaviruses sp.( ) ssRNA Influenza virus A, B, COrthomyxoviridae f.( ) ssRNA (AIDS) Human immunodeficiency virus(HIV)(Lentivirus spp.) A.4 4 , Yellow fever virusFlavivirus spp.( ) ssRNA Dengue virusFlavivirus spp.( ) ssRNA Marburg virusFilovirus
17、spp.( ) ssRNA Ebola virusFilovirus spp.( ) ssRNA Lassa virusArenavirus spp.( / ) ssRNA Leishmania donovani, L. infantum, L. tropica complex, L. major, L. aethiopica L. mexicana complex, L. braziliensis Babesia microti, B. divergens KS J 0050 3:2010 7 Trypanosoma brucei gambiense, T. b. rhodesiense C
18、ryptosporidium parvum, C. muris, C. baileyi Schistosoma japonicum, S. mansoni, S. haematobium reponema pallidum subsp. pertenue Treponema carateus Variola virus(Orthopoxvirus spp.) Clostridium botulinum , , , A.5 1 4 A Hepatitis A Virus(HAV)(Hepatovirus spp.) C Hepatitis C Virus (VRSA) Vancomycin-re
19、sistant Staphylococcus aureus Trypanosoma cruzi Angiostrongylus cantonensis Gnathostoma spinigerum Wuchereria bancrofti, Brugia malayi, Brugia timori, Loa loa, Onchocerca volvulus Echinococcus granulosus, E. multilocularis Prion Protein(PrP) KS J 0050 3:2010 8 B ( ) (OIE list) (Terrestrial Animal He
20、alth Code) (List A, B, C)1) . B.1 List A . , . . B.2 List B . . 1 . ( , Epizootic lymphangitis) Histoplasma capsulatum var. farcinimosum 1) 4 . a) ? b) ? c) ? d) ? KS J 0050 3:2010 9 1 FAO/WHO, Safety assessment of foods derived from genetically modified microorganisms, a joint FAO/WHO expert consul
21、tation on foods derived from biotechnology, Geneva, Switzerland, 24 to 28 September 2001(2001) 2 FAO/WHO, Evaluation of the allergenicity of genetically modified foods., a Joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology, Rome, Italy, 22 to 25 January 2001(2001)
22、 3 ( ), Guidelines for Laboratory Diagnosis of Statutory Communicable Diseases( ), Korea Center for Disease Control and Prevention(2002) 4 (National Veterinary Research and Quarantine Service)： http： www.nvrqs.go.kr/ 5 (National Fisheries Research and Development Institute), ：http:/www.nfrda.re.kr/
23、6 World Health Organization, Laboratory Biosafety Manual, WHO/CDS/CSR/LYO/2003.4 , 2nd ed., Geneva(2003) 7 The Office International des Epizooties： http： /www.oie.int/eng/en_index.htm 8 European Economic Community, Council Directive 93/88/EEC of 12 oct. 1993 amending Directive 90/679/EEC on the prot
24、ection of workers from risks related to exposure to biological agents at work(7th individual Directive within the meaning of Article 16(1) of Directive 89/391/EEC)(1993) 9 Japan National Institute of Infectious Diseases： http： /www.nih.go.jp/niid/index.html 10 Japan National Institute of Animal Heal
25、th： http： /niah.naro.affrc.go.jp 11 National Institutes of Health, NIH guidelines for research involving recombinant DNA molecules(NIH guidelines), April 2002(2002)： http： /www4.od.nih.gov/oba 12 Centers for Disease Control and Prevention and National Institutes of Health, Biosafety in Microbiologic
26、al and Biomedical Laboratories, 4th ed., May 1999, US Government Printing Office, Washington(1999) 13 Animal and Plant Health Inspection Service(APHIS)： http:/www.aphis.usda.gov/ 14 American Biological Safety Association, Risk Group Classification for Infectious Agents(1998)：http:/www.absa.org/resri
27、skgroup.html 15 Public Health Agency of Canada, Laboratory Biosafety Guidelines, 2nd ed.(1996)： http:/www.phac-aspc.gc.ca/publicat/lbg-ldmbl-96/ 16 DSMZ Bacterial Nomenclature Up-to Date, DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany(1998)： http:/www.gbf.de/start-en/ 3： 153787 1 92 3(13) (02)26240114 (02)262401489 http:/ KS J 0050 3:2010 KSKSKS SKSKS KSKS SKS KS SKS KSKS SKSKS KSKSKS BioindustryPathogen list and its biosafety classPart 3：Fungi ICS 07.080 Korean Agency for Technology and Standards http:/www.kats.go.kr
