GOST 32639-2014 OECD guidelines for the testing of chemicals Subchronic dermal toxicity 90-day study《化学品试验OECD指南 亚慢性经皮毒性 为期90天的研究》.pdf

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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32639 2014 : 90- (OECD, Test 411:1981, IDT) 326392014 II , 1.092 . 1.22009 . , , . , , 1 - , , ( ); 339 , 2 3 , ( 30 2014 . 67-) : ( 3166) 004 97 ( 3166) 004 97 AM BY KG MD RU TJ - 4 OECD 411:1981 Subchronic Dermal Toxic

2、ity: 90-day Study (, 411:1981 : 90- ). (en). (IDT) 5 3 2014 . 1267- 326392014 1 2015 . 6 , . () . , , 2015 , 326392014 III . , . 326392014 1 : 90- OECD guidelines for the testing of chemicals. Subchronic Dermal Toxicity: 90-day Study 20150601 1 90 . 2 : 2.1 (Dose in a dermal test): , ( ). (, ) (, /)

3、 2.2 (Cumulative toxicity): , . 2.3 (Subchronic dermal toxicity): , ( 10 ) . 2.4 NOAEL (No-effect level/No-toxic-effect level/No-adverse-effect level): , , . 3 , , 90 . : - : - - () - - ph ( ) - , , - / . , , , . 326392014 2 4 4.1 , , 5 . . . , 24 . . , , , , . 10 . , . , , , . . . 4.2 4.2.1 : , .

4、 . : - (200 - 300 ), - (2,0 - 3,0 ), - (350 - 450 ). , . 4.2.2 , , 20 (10 10 ) . . , , . , 20 ( 10 ) 90 , , , 28 . 4.2.3 . 22 ( 3 ) 20 C ( 3 ) 30-70 . : 12 - 12 - . . 4.3 4.3.1 , , , . , , . , , . . , , . , (-) (-) . , , . , . , , 326392014 3 . , , . 4.3.2 , 1000 / ( ), , , , , , . 4.3.3 , . , , , , , . 4.4 6 7 90 . , , , 5 . , , 28 , . , 10 . , . , . , , , , , . , , . , , , . : , , , , , , . . , , , . . . 4.5 : - , , , , . . - , , , , , , , , , . - . , , , ( ), . . - , , , , , ( ), 326392014 4 1,

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