GOST 32646-2014 OECD guidelines for the testing of chemicals Acute inhalation toxicity - acute toxic class (ATC) method《化学品试验OECD指南 急性吸入毒性 急性毒性分类 (ATC) 方法》.pdf

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GOST 32646-2014 OECD guidelines for the testing of chemicals Acute inhalation toxicity - acute toxic class (ATC) method《化学品试验OECD指南 急性吸入毒性 急性毒性分类 (ATC) 方法》.pdf_第1页
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GOST 32646-2014 OECD guidelines for the testing of chemicals Acute inhalation toxicity - acute toxic class (ATC) method《化学品试验OECD指南 急性吸入毒性 急性毒性分类 (ATC) 方法》.pdf_第5页
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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32646 2014 ( ) (OECD, Test 436:2008, IDT) 326462014 II , 1.092 . 1.22009 . , , . , , 1 - , , ( ); 339 , 2 3 , ( 28 2014 . 65- ) : ( 3166) 004 97 ( 3166) 004 97 AZ AM BY KG MD RU TJ - 4 06 2014 . 1272- 326462014 01 2015 .

2、 5 OECD Test 436:2008 Acute Inhalation Toxicity - Acute Toxic Class (ATC) Method (, 436:2008 ( ATC) (en). (IDT) 6 , . () . , , 2015 , 326462014 III - , . 403 1981 , 2. () 3, 4, 5 (TG 423) 6 2001 . ATC , 7. ATC . . , , , . 19 8. 39 (GD 39) 9. , , GD 39 9. 326462014 1 ( ) OECD guidelines for the testi

3、ng of chemicals Acute Inhalation Toxicity - Acute Toxic Class (ATC) Method 2015 06 01 1 ( , ) 10. , CL50/LC50, 403 2. GD 39 9. , , , . , , , , . , , , , , - ; in vitro in vivo ; ; (Q)SAR . , 1, (. GD 39 9).2 . 4- , . . . / , . , , . , : ) ; b) 3 , c) 6 , 6 1 : , in vitro, , TG 430 11, 431 12 435 13,

4、 , . 326462014 2 , . , , , . , , . , , , 19 8. 3 3.1 . , . 3.2 . 8 12 , 20% . . , , 5 . , , , . 3.3 22 30. 30 70%, . , , . , . , . , . , () / . , , , . , , . , , , . , 12 / 12 . 3.4 . ( , , ). , , , , . , . , , , 5% . , GD 39 9. 326462014 3 4 4.1 , , . , (. GD 39 9). , , . , . , , , . , , - , / , . . , . 4.2 , . () 1 4 (g) 1,5 3,0 9, 14, 15. , , . , , , ( ) . 4.3 . , .

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