GOST 33059-2014 Testing of chemicals of environmental hazard Avian acute oral toxicity test《环境危害化学品试验 鸟类的急性经口毒性试验》.pdf

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1、 , : (OECD, Test No 223:2010, IDT) , ()INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION(ISC)330592014, 1.092 . 1.22009 . , - . , , -, 1 - , , - ( ) , 52 (-)3 , (- 20 2014 . 71-) : ( 3166) 00497 ( 3166) 00497 AZAMBYKGMDRUTJ -4 25 2014 . 1749- 330592014 - 1 2015 .5 OECD Test No 223:

2、2010 Avian AcuteOral Toxicity Test (: ). (en). (IDT)6 - , - . () - . , , 2015 -, II 3305920141 12 33 34 45 56 .57 78 .13 () , .15 B () 17 C () LD50 , 18 19III 330592014 , : Test methods for chemicals of environmental hazard. Avian acute oral toxicity test 201508011 1.1 , , - . :- , . - , 2000 / . 51

3、0 ( 1);1 330592014 1 ( )- LD50- , - - / , LD50. 34 2434 - ( 2)1);- LD50- , - ( ), - LD50 . ( LD50) , . - 14 ( 2).1) - - (. USEPA OPPTS 850.2100). , ( USEPA OPPTS 850.2100), .2 3305920142 ( LD50- LD50-); . , , 7.2.2.27.2.2.51.2 LD50- (- 2). , . , - , , , LD50-. .1.3 , 2. - LD50, -.1.4 LD50-, , , LD50

4、. 14 , - , . , - , , .1.5 ( ) ( ), . 1, , LD50(, , - ). 1, () LD50. - 2 (Maximum LikelihoodEstimation (MLE), 10 . - LD50 , - 2. LD50- 3 , 4 ( 7.2.2.27.2.2.5).2 - .3 :3.1 (acute oral toxicity): , - 24 .3.2 (dose): . (, ), (, / ).3.3 LD50( ) (median lethal oral dose): - , 50 % - . LD50 (/ ).3.4 (limit

5、 dose): .3.5 (probit): probability integral transformation; - - - ( - ) ( ), - , . - , , LD50.3 3305920143.6 - (slope of the dose-response curve): - . -, - , , , , - .3.7 ( ) (stage in a sequential design): - , - . LD50 -, . , , .3.8 ldose: , (/ ).3.9 hdose: , (/ ).3.10 step: () .3.11 LD50(initial e

6、stimate of the LD50): , () , 1.3.12 LD50 - (working estimate of LD50andslope): , - . - , .3.13 LD50 - (final estimates of LD50andslope): , . - , 14 .3.14 (partial kills): , , , . - .3.15 (reversals): , , ( ) , , . , -, LD50. , , , , , , - , 0001011111 000110111, , 0001010111 00011010011 . .4 4.1 . - (/ ) , . - , ( -). , , - , . , . 1 2 , 3 4 . 1 - LD50(, , ). , , , LD50 - .4.2 14 , - . , , . - , . - 14 , ., , ( 4 330592014 ). , , . , , , , - 2. () 3- . 3- , , LD50 , ,

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