1、raising standards worldwideNO COPYING WITHOUT BSI PERMISSION EXCEPT AS PERMITTED BY COPYRIGHT LAWBSI Standards PublicationBS ISO 30011:2010Workplace air Determinationof metals and metalloids inairborne particulate matterby inductively coupled plasmamass spectrometryBS ISO 30011:2010 BRITISH STANDARD
2、National forewordThis British Standard is the UK implementation of ISO 30011:2010.The UK participation in its preparation was entrusted to TechnicalCommittee EH/2/2, Work place atmospheres.A list of organizations represented on this committee can beobtained on request to its secretary.This publicati
3、on does not purport to include all the necessaryprovisions of a contract. Users are responsible for its correctapplication. BSI 2011ISBN 978 0 580 58962 1ICS 13.040.30Compliance with a British Standard cannot confer immunity fromlegal obligations.This British Standard was published under the authori
4、ty of theStandards Policy and Strategy Committee on 31 January 2011.Amendments issued since publicationDate Text affectedBS ISO 30011:2010Reference numberISO 30011:2010(E)ISO 2010INTERNATIONAL STANDARD ISO30011First edition2010-10-01Workplace air Determination of metals and metalloids in airborne pa
5、rticulate matter by inductively coupled plasma mass spectrometry Air des lieux de travail Dtermination des mtaux et mtallodes dans les particules en suspension dans lair par spectromtrie de masse avec plasma couplage inductif BS ISO 30011:2010ISO 30011:2010(E) PDF disclaimer This PDF file may contai
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7、ty of not infringing Adobes licensing policy. The ISO Central Secretariat accepts no liability in this area. Adobe is a trademark of Adobe Systems Incorporated. Details of the software products used to create this PDF file can be found in the General Info relative to the file; the PDF-creation param
8、eters were optimized for printing. Every care has been taken to ensure that the file is suitable for use by ISO member bodies. In the unlikely event that a problem relating to it is found, please inform the Central Secretariat at the address given below. COPYRIGHT PROTECTED DOCUMENT ISO 2010 All rig
9、hts reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying and microfilm, without permission in writing from either ISO at the address below or ISOs member body in the country of th
10、e requester. ISO copyright office Case postale 56 CH-1211 Geneva 20 Tel. + 41 22 749 01 11 Fax + 41 22 749 09 47 E-mail copyrightiso.org Web www.iso.org Published in Switzerland ii ISO 2010 All rights reservedBS ISO 30011:2010ISO 30011:2010(E) ISO 2010 All rights reserved iiiContents Page Foreword i
11、v Introduction.v 1 Scope1 2 Normative references2 3 Terms and definitions .2 3.1 General definitions 2 3.2 Analytical definitions 3 3.3 ICP-MS definitions.6 3.4 Statistical definitions 8 4 Principle10 5 Requirements.10 6 Reagents.10 7 Laboratory apparatus13 8 Procedure.13 8.1 Preparation of sample s
12、olutions13 8.2 Method development.14 8.3 Instrument performance checks18 8.4 Routine analysis 18 8.5 Estimation of detection and quantification limits 20 8.6 Quality control .20 8.7 Measurement uncertainty.21 9 Expression of results22 10 Method performance .22 10.1 Method detection limits and quanti
13、fication limits22 10.2 Upper limits of the analytical range.22 10.3 Bias and precision.23 10.4 Measurement uncertainty.24 11 Test report24 11.1 Test records .24 11.2 Laboratory report 25 Annex A (informative) ICP-MS principles and interferences 26 Annex B (informative) Guidance on maintenance of ICP
14、-MS instrumentation 29 Annex C (informative) Recalculation of metal and metalloid in air concentrations to reference conditions.31 Bibliography32 BS ISO 30011:2010ISO 30011:2010(E) iv ISO 2010 All rights reservedForeword ISO (the International Organization for Standardization) is a worldwide federat
15、ion of national standards bodies (ISO member bodies). The work of preparing International Standards is normally carried out through ISO technical committees. Each member body interested in a subject for which a technical committee has been established has the right to be represented on that committe
16、e. International organizations, governmental and non-governmental, in liaison with ISO, also take part in the work. ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of electrotechnical standardization. International Standards are drafted in accordance
17、with the rules given in the ISO/IEC Directives, Part 2. The main task of technical committees is to prepare International Standards. Draft International Standards adopted by the technical committees are circulated to the member bodies for voting. Publication as an International Standard requires app
18、roval by at least 75 % of the member bodies casting a vote. Attention is drawn to the possibility that some of the elements of this document may be the subject of patent rights. ISO shall not be held responsible for identifying any or all such patent rights. ISO 30011 was prepared by Technical Commi
19、ttee ISO/TC 146, Air quality, Subcommittee SC 2, Workplace atmospheres. BS ISO 30011:2010ISO 30011:2010(E) ISO 2010 All rights reserved vIntroduction The health of workers in many industries is at risk through exposure by inhalation of toxic metals and metalloids. Industrial hygienists and other pub
20、lic health professionals need to determine the effectiveness of measures taken to control workers exposure, and this is generally achieved by taking workplace air measurements. ISO 30011 has been published in order to make available a method for making valid ultra-trace exposure measurements for a w
21、ide range of metals and metalloids in use in industry. It is intended for: agencies concerned with health and safety at work; industrial hygienists and other public health professionals; analytical laboratories; and industrial users of metals and metalloids and their workers. ISO 30011 specifies a m
22、ethod for determination of the mass concentration of metals and metalloids in workplace air using quadrupole inductively coupled plasma mass spectrometry (ICP-MS). For many metals and metalloids, analysis by ICP-MS is advantageous when compared to methods such as inductively coupled plasma atomic em
23、ission spectrometry, due to its sensitivity and the presence of fewer spectral interferences. ISO 30011 gives requirements and test methods for analysis of sample solutions by ICP-MS. Users of ISO 30011 are referred to ISO 15202-1 for collection of samples of airborne particulate matter and to ISO 1
24、5202-2 for procedures for preparing sample solutions for analysis by ICP-MS. It has been assumed in the drafting of ISO 30011 that the execution of its provisions, and the interpretation of the results obtained, are entrusted to appropriately qualified and experienced people. BS ISO 30011:2010BS ISO
25、 30011:2010INTERNATIONAL STANDARD ISO 30011:2010(E) ISO 2010 All rights reserved 1Workplace air Determination of metals and metalloids in airborne particulate matter by inductively coupled plasma mass spectrometry 1 Scope This International Standard specifies a procedure for the use of quadrupole in
26、ductively coupled plasma mass spectrometry (ICP-MS) for analysing test solutions prepared from samples of airborne particulate matter collected as specified in ISO 15202-1. Method development, performance checks, and a routine analysis method are specified. Test solutions for analysis by this Intern
27、ational Standard are prepared as specified in ISO 15202-2. This International Standard is applicable to the assessment of workplace exposure to metals and metalloids for comparison with limit values (see e.g. EN 68910, ASTM E13708). The following is a non-exclusive list of metals and metalloids for
28、which limit values have been set (see Reference 15) and for which one or more of the sample preparation methods specified in ISO 15202-2 and the analytical procedure described in this International Standard are applicable. However, there is no information available on the effectiveness of any of the
29、se sample preparation methods for those elements listed in italics. aluminium caesium lead platinum tungsten antimony chromium lithium potassium uranium arsenic cobalt magnesium rhodium vanadiumbarium copper manganese selenium yttrium beryllium gallium mercury silver zincbismuth germanium molybdenum
30、 sodium zirconium boron hafnium nickel tellurium cadmium indium niobium thallium calcium iron phosphorus tin This International Standard is not applicable to determination of elemental mercury, since mercury vapour is not collected using the sampling method specified in ISO 15202-1. The procedure is
31、 suitable for assessment of exposure against the long-term exposure limits for most of the metals and metalloids listed above when sampling at a typical flow rate of 2 l min1for sampling times in the range 0,5 h to 8 h and for assessment of exposure against the short-term exposure limits, where appl
32、icable. The procedure is subject to no significant spectral interferences (see A.3), provided that suitable analytical isotopes are used. However, inadequate matrix-matching can adversely affect results. BS ISO 30011:2010ISO 30011:2010(E) 2 ISO 2010 All rights reserved2 Normative references The foll
33、owing referenced documents are indispensable for the application of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies. ISO 1042, Laboratory glassware One-mark volumetric flasks
34、 ISO 3585, Borosilicate glass 3.3 Properties ISO 8655-1, Piston-operated volumetric apparatus Part 1: Terminology, general requirements and user recommendations ISO 8655-2, Piston-operated volumetric apparatus Part 2: Piston pipettes ISO 8655-5, Piston-operated volumetric apparatus Part 5: Dispenser
35、s ISO 8655-6, Piston-operated volumetric apparatus Part 6: Gravimetric methods for the determination of measurement error ISO 15202-1, Workplace air Determination of metals and metalloids in airborne particulate matter by inductively coupled plasma atomic emission spectrometry Part 1: Sampling ISO 1
36、5202-2:, Workplace air Determination of metals and metalloids in airborne particulate matter by inductively coupled plasma atomic emission spectrometry Part 2: Sample preparation 3 Terms and definitions For the purposes of this document, the following terms and definitions apply. 3.1 General definit
37、ions 3.1.1 breathing zone general definition space around the workers face from where he or she takes his or her breath NOTE Adapted from EN 1540:11, 2.4.5. 3.1.2 breathing zone technical definition hemisphere (generally accepted to be 0,3 m in radius) extending in front of the human face, centred o
38、n the midpoint of a line joining the ears; the base of the hemisphere is a plane through this line, the top of the head, and the larynx NOTE 1 The definition is not applicable when respiratory protective equipment is used. NOTE 2 Adapted from EN 1540:11, 2.4.5. 3.1.3 chemical agent any chemical elem
39、ent or compound, on its own or admixed as it occurs in the natural state or as produced, used or released including release as waste, by any work activity, whether or not produced intentionally and whether or not placed on the market Council Directive 98/24/EC16, Art. 2(a) BS ISO 30011:2010ISO 30011
40、:2010(E) ISO 2010 All rights reserved 33.1.4 exposure by inhalation situation in which a chemical agent is present in the air that is inhaled by a person NOTE Adapted from EN 1540:11, 2.4.1. 3.1.5 occupational exposure limit value limit of the time-weighted average of the concentration of a chemical
41、 agent in the air within the breathing zone of a worker in relation to a specified reference period Council Directive 98/24/EC16, Art. 2(d) EXAMPLES Threshold Limit Values(TLVs) established by the ACGIH (Reference 15) and Indicative Occupational Exposure Limit Values (IOELVs) promulgated by the Euro
42、pean Commission (Council Directive 2006/15/EC17). 3.1.6 measuring procedure for the sampling and analysis of chemical agents in air measurement procedure for the sampling and analysis of chemical agents in air set of operations, described specifically, used for the sampling and analysis of chemical
43、agents in air NOTE 1 A measuring procedure for the sampling and analysis of chemical agents in air usually includes the following steps: preparation for sampling, sampling, transportation and storage, preparation of samples for analysis and analysis. NOTE 2 Adapted from ISO/IEC Guide 99:20074. 3.1.7
44、 reference period specified period of time for which the limit value of a chemical agent applies NOTE 1 The reference period is usually 8 h for long-term measurements and 15 min for short-term measurements. NOTE 2 Adapted from EN 1540:11, 2.4.7. 3.1.8 workplace defined area or areas in which the wor
45、k activities are carried out EN 1540:11, 2.5.2 3.2 Analytical definitions 3.2.1 analysis all operations carried out after sample preparation to determine the amount or concentration of the analyte(s) of interest present in the sample NOTE Adapted from EN 14902:200513, 3.1.1. 3.2.2 blank solution sol
46、ution prepared by taking a reagent blank, laboratory blank or field blank through the same procedure used for sample dissolution NOTE 1 A blank solution might need to be subjected to further operations, such as addition of an internal standard, if the sample solutions are subjected to such operation
47、s in order to produce test solutions that are ready for analysis. NOTE 2 Adapted from EN 14902:200513, 3.1.2. BS ISO 30011:2010ISO 30011:2010(E) 4 ISO 2010 All rights reserved3.2.3 calibration blank solution calibration solution prepared without the addition of any stock standard solution or working
48、 standard solution NOTE 1 The concentration of the analyte(s) of interest in the calibration blank solution is taken to be zero. NOTE 2 Adapted from EN 14902:200513, 3.1.3. 3.2.4 calibration curve plot of instrument response versus concentration of standards NOTE Adapted from United States Environme
49、ntal Protection Agency (Reference 18). 3.2.5 calibration solution solution prepared by dilution of the stock standard solution(s) or working standard solution(s), containing the analyte(s) of interest at a concentration(s) that is suitable for use in calibration of the analytical instrument NOTE 1 The matrix-matching technique is normally used when preparing calibration solutions. NOTE 2 Adapted from EN 14902:200513, 3.1.4. 3.2.6 field blank sampling medium tha
