GOST 32437-2013 Testing of chemicals of human hazard Chronic toxicity studies《人类危险化学品测试 慢性毒性研究》.pdf

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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32437 2013 (OECD, Test No452:2008, IDT) 2014 324372013 II , - 1.092 . - 1.22009 . -, . , -, , 1 - ( - ); - , , - ( ) 2 3 , ( 61- 5 2013 .) : ( 3166) 004 97 ( 3166) 004 97 AM BY KG MD RU TJ - 4 OECD, Test 452 Chronic Toxi

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3、011 -. - , - . , , : , ; ; in vitro in vivo ; - ; (Q)SAR - ; (- , ) , - . 28 / 90 3, 4. - . , - . - , - . - , (NOAEL), - . . - , 5 , , , , 5. - . . , , . - . -, . . - . 1 324372013 2 2 -: 2.1 : (dose) . (, ), (/). 2.2 (Dosage): , , . 2.3 , (NOAEL): (Identification of a no-observed-adverse-effect lev

4、el) , - , . 3 - 12 , . , , - , . 12 , . . - , , . . , , . - . 4 4.1 4.1.1 , - . . - , , , . 2. , , , . , - , . . . , , - . -. 4.1.2 - . , . , . - (223). - , 30 % 70 % ( ), 50 % 60 %. - 12 , 12 . - . . , ( , , -, ), . - -, , , . - , . 4.1.3 , 324372013 3 , , . , , . - , , , , . - 20 % - , , . . - . , . - , - , , . 24 ( ) . -, , . 10 % . 4.2 4.2.1 , - - . , 20 , 4 . , ,

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