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GOST 32641-2014 OECD guidelines for the testing of chemicals Repeated dose 28-day oral toxicity study in rodents《化学品试验OECD指南 对啮齿类动物重复28天口服剂量的毒性研究》.pdf

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GOST 32641-2014 OECD guidelines for the testing of chemicals Repeated dose 28-day oral toxicity study in rodents《化学品试验OECD指南 对啮齿类动物重复28天口服剂量的毒性研究》.pdf_第1页
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1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32641 2014 / . 28- (OECD, Test 407:2008, IDT) 326412014 II , 1.092 . 1.22009 . , , . , , 1 ( ); - , , ( ); 339 , 2 3 , ( 28 2014 . 65-) : ( 3166) 004 97 ( 3166) 004 97 AZ AM BY KZ KG MD RU TJ TM UZ UA - 4 OECD Test 407:

2、2008 Repeated Dose 28-Day Oral Toxicity Study in Rodents ( 407: 2008 : 28 - ). (en). (IDT) 5 24 2014 . 1215- 326412014 1 2015 . 6 326412014 III , . () . , , 2015 , 326412014 IV 407 1981 . . 1995 . , , , . 1998 . () 9. 28- , . , (), () () , , 407. , , 10. 407 , . 326412014 1 / . 28- OECD guidelines f

3、or the testing of chemicals. Repeated dose 28-day oral toxicity study in rodents 20150601 1 , , . . , , , . - , , , , . , / . , , . 12. , 90- (, ) . 28 . , , , , , , . , , , . 20. . , , . , , , , , (. 6). , , , () () 10. , . , , , ; , , , , , . , . 326412014 2 , , . , , , , , . ( ) , . , , ; , , . 1

4、5. 2 : 2.1 (Androgenicity): (, ) . 2.2 (Antiandrogenicity): (, ) . 2.3 (Antithyroid activity): (, 3) . 2.4 (Antioestrogenicity): (, 17) . 2.5 (Validation): , . 2.6 (Dose): . (, ), (, /), . 2.7 (Dosage): , , . 2.8 (Evident toxicity): , . , . 2.9 (Thyroid activity): (, 3) . 2.10 (Oestrogenicity): (, 17) . 2.11 NOAEL: , , . 3 , , , 28 . . , , ; . 28- , . 326412014 3 , . , , (NOAEL). 4 4.1 4.1.1 , . , , , . , , - . . . . , , ,

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