1、Introduction to World Traditional Medicine Patent Database (WTMPD),Beijing East Linden Science & Technology Co., Ltd Tel:+86 10 5129 6683 Fax:+86 10 8207 4085 Email:,Main Components,prologue,World traditional medicine patent database (WTM) produced by East Linden is the worlds first bilingual (Engl
2、ish and Chinese) traditional medicine patent database with integration of multinational patent resources.Based on high-quality manually processed/indexed/translated data, assisted by five auxiliary files as well as two facilitating helping tools, plus functional search engine which provides multiple
3、 search entries, WTMPD is a valuable patent information resource in terms of providing professional search capabilities and analytical tools for global research academies and enterprises in the field of natural medicine research and drug development. Besides, natural products with pharmaceutical, nu
4、traceutical, cosmetic and agrochemical interest are also included.This file will present a detailed introduction to the database from the following five aspects. 1. Introduction to Manually Processed & Deeply-indexed Data 2. Introduction to Auxiliary Files 3. Introduction to Helping Tools 4. Introdu
5、ction to Search & Analyzing Platform 5. Introduction to Search Queries & Results Management Interface,1. Manually Processed & Deeply-indexed Data,Outline,1.1 A Full Record Sample 1.2 Data Description 1.3 Rewritten Title 1.4 Enhanced Abstract 1.5 Unifying IPC Format & Supplementing IPC 1.6 Index Term
6、s 1.7 Indexed Term Codes 1.8 Therapeutic Effects Indexation 1.9 TCM Formulae,A Full Record Sample,1.1,Data Description,1.2,Data Coverage: China, United States, Japan, Korea, Austria, Canada, Switzerland, East Germany, France, South Africa, Spain, Great Britain, Ireland, Israel, India, Netherlands, N
7、ew Zealand, Philippines, Russia, Soviet Union, Singapore, Taiwan, EPO, WIPOTime Scope: 1985 to dateIPC Coverage: A61K35 A61K33 A23L A61K9 A61K31 A61K7 A61K38 A61K49 A61K47 A61K39 C12N1/14 A01G1/04 A61K36 A61K8 A61P,Rewritten Title,Rewritten Title,1.3,More descriptive information added to the title:
8、Name of drug or product, drug ingredients Method of preparation Novelty Physiological activity or biological mechanism Uses,1.PN:US6004559 Original Title : Nontoxic extract of larrea tridentata and method of making the same Rewritten Title: Nontoxic, therapeutic agent prepared with extract of larrea
9、 tridentata for the treatment diseases caused by viruses and inflammatory diseases, and method of making the same 2. PN: WO0191770 Original Title : Compositions and methods for treating eye discomfort Rewritten Title : Compositions containing herbals, natural nutritional supplements, minerals and vi
10、tamins and methods for treating eye discomfort,Samples,More descriptive information about technique is added to abstracts: The subject or purpose of the invention Standardization of compound or medicine name Method of preparation Advantages Physiological activity or biological mechanism Uses Means o
11、f taking medicine,Enhanced Abstract,1.4,PN: US5012761 Original Abstract: Chickens are fed a composition including fish oil over a period of time. Modified eggs laid by such chickens contain substantial quantities of omega-3 polyunsaturated fatty acids. The modified eggs are fed to humans with the re
12、sult that serum cholesterol, serum triglycerides and blood pressure are reduced a compared to human eating a like number of regular eggs with a subsequent decrease in heart disease. Enhanced Abstract: A method of increasing the OMEGA-3 polyunsaturated fatty acid content of chicken eggs comprises the
13、 steps of: (a) obtaining a grain based chicken feed; (b) forming a mixture of the chicken feed and an oil containing OMEGA-3 polyunsaturated fatty acid such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with the oil being from about 3.0 percent to about 10.0 percent by weight of the
14、mixture; (c) thereafter feeding chicken laying hens the mixture as a primary source of food for the hens; and (d) collecting the eggs of such hens laid subsequent to the hens eating the mixture. The oil is fish oil, and fish oil may be deodorized. Said hen eggs contain low cholesterol content, which
15、 can be fed to humans with the result that serum cholesterol, serum triglycerides, very low density lipoprotein and blood pressure are reduced as compared to humans eating a like number of regular eggs with a subsequent decrease in heart disease for example coronary heart disease.,Sample 1,PN: US200
16、20082780 Original Abstract: Therapeutic compositions made from the herb Tribulus terrestris and methods of making and using the same are provided, The therapeutic compositions include an enriched extract having an increased spirostanol saponin content that is prepared from the harvested Tribulus ter
17、restris L. The enriched extract is prepared using discrete hydrolysis, separation and enrichment steps. The resulting therapeutic may be combined with a cream base and is useful for treating bacterial, fungal, and viral infections, particularly gynecologic infections. This product was also found to
18、be very successful in suppository form for the treatment of vulvo-vaginal, vulvo-hemorrhoidal and colonic conditions. Enhanced Abstract: An anti-bacterial, anti-virus, anti-herpes topical medication comprising extract of Tribulus terrestris L. (Tribulus terrestris, Puncture Vine, Caltrop fruit) is p
19、repared by the steps of: (a) Preparing an aqueous first extract of Tribulus terrestris L; (b) Treating the first extract to convert furostanol saponin compounds of protodioscine contained therein to spirostanol saponin compounds of diosgenin by BETA-Glucosidase or acid hydrolysis; (c) isolating the
20、spirostanol compounds from the first extract; and (d) adding the isolated spirostanol compounds to second Tribulus terrestris L extract. The resulting therapeutic medication may be formulated into cream, ointments, eye and ear drops. It is useful in the treatment of conditions related to viral, bact
21、erial, fungal, viral, yeast, parasitic infections, particularly gynecologic infections, including genital, and eye and ear infections, vaginal infections, candidiasis, skin disorders such as skin infection, acne, skin burning and rashes, herpes simplex I, herpes simplex II, cervical wounds, cervical
22、 erosion, diabetic wounds, Burger disease, phlebitis, varicose veins and broken split skin. It may block cancer cells from growing. It also can be used for the treatment of vulvo-vaginal, vulvo-hemorrhoidal and colonic conditions in the form of suppository.,Sample 2,Unified IPC format, making IPC fo
23、rmat more standard IF the subject of the patent is about USE (Therapeutic Effects), IPC A61P will be added to the patent record IF the subject of the patent is about FOR ( Formulation Process), IPC A61K009 will be added to the patent record IF a patent is about a medicine relevant to plant or epiphy
24、te, IPC A61K035/78 and A61K035/84 will be added to the patent record,Unifying IPC Format and Supplementing IPC,1.5,PN: US6004559 Original IPC:A23C 9/00; A23L 1/304; A23L 2/00; A23L 2/40 After:A23C009/00; A23L001/304; A23L002/00; A23L002/40; A23C009/152; A23L002/52; A23L002/42; A23L002/44; A23L002/54
25、 A23L002/54; A61P003/02,Sample,Supplementing A61P based on IPC7,Indexing Terms,1.6,All Traditional Medicine , Specific Compounds , Generic Structure , Animal Medicine, Plant Medicine existing in the patent document are indexed to support a special search,PN:US6368641 Abstract: Lactic acid food produ
26、cts comprise a starter for use in producing lactic acid food products and soy milk or a mixture of soy-milk and dairy milk. The starter comprises Lactobacillus acidophilus strain 317/402, Lactobacillus acidophilus non-mucus producing strain, Streptococcus diacetilactis, Lactobacillus salivarius, Str
27、eptococcus cremoris. The lactic acid food products can be made into sour cream, cottage cheese, lactic acid desserts, dry drinks, ice cream, frozen dessert. Lactic acid food products can be used in a normal diet or in medicine both for their nutritive value, and for the physiologically active substa
28、nces they contain. It can be used for the medical treatment of health problems such as gastrointestinal disorders (such as gastritis, hyperemia, and ulcer of a stomach), pulmonary disease and allergies. It also can be used as part of a medical treatment to promote the growth of the natural microflor
29、a of intestine and to lower cholesterol levels in the blood. Indexed Terms: SOY MILK; DAIRY MILK; LACTOBACILLUS ACIDOPHILUS STRAIN 317/402; LACTOBACILLUS ACIDOPHILUS NON MUCUS PRODUCING STRAIN; STREPTOCOCCUS DIACETILACTIS; LACTOBACILLUS SALIVARIUS; STREPTOCOCCUS CREMORIS; LACTIC ACID FOOD PRODUCT; S
30、OUR CREAM; COTTAGE CHEESE; LACTIC ACID DESSERTS; DRYDRINKS; ICE CREAM; FROZEN DESSERT,Sample,Indexed Term Codes,1.7,According to subject of the patent, all patents in the database are classified into eight categories with different Indexed Term Codes (ITC) as below,ITC: COM (COMBINATION PROCESS) PN:
31、US20040115163 Abstract:A cosmetic product with skin-aging retarding effect comprises vegetable lipidic extracts. The lipidic extracts include sea fennel wax, Cistus monspeliensis wax, Helichrysum italicum wax and Lavandula stoechas wax, which are prepared from Crithmum maritimum (sea fennel, Apiacea
32、e family, Crithmum genus), Cistus monspeliensis (Cistaceae family, Cistus genus), Helichrysum italicum (Asteraceae family, Helichrysum genus) and Lavandula stoechas (Lamiaceae family, Lavandula genus) by means of supercritical CO2 co-extraction in the presence of a solvent composed of vegetal origin
33、 triglycerides. And a vegetable oil which is solid at room temperature is added to the lipidic extracts. The cosmetic product can be available in the form of a vegetal wax; and can be used as a food supplement. The vegetal waxes act both on epidermal differentiation and on keratinocyte division. The
34、y have effect in retarding skin aging. They also may be used in dermatology as the active principle of a pharmaceutical product to treat the disorders of keratinocyte differentiation, in particular as an anti-psoriatic agent; and moreover may be used as the active principle of a pharmaceutical used
35、in speeding up scar formation. .,Sample 1,ITC:EXT (EXTRACTION PROCESS ) PN:US20060057238 Abstact: A method of making extract of buds of cryptomeria japonica D. Don (Taxodiaceae, Cryptomeria japonica) includes three stages, first solid/liquid extraction stage at a temperature between 3-100 with water
36、, alcohol (such as butylene glycol) or a polyol, followed by a second solid/liquid separation step, then a third liquid phase retrieval step. The solid/liquid extraction step is performed by maceration, digestion, fluid bed extraction, microwave-assisted extraction, ultrasound-assisted extraction, c
37、ountercurrent extraction, percolation, repercolation, leaching, low-pressure extraction, supercritical fluid extraction and so on.Said extract can be used to make face cream, Slimming Body Milk, O/W Emulsion, W/O Emulsion, Microemulsion, Sunscreen, Makeup Foundation and so on.,Sample 2,ITC: FOR (FOR
38、MULATION PROCESS ) PN: US5012761 Abstrac: A method of increasing the OMEGA-3 polyunsaturated fatty acid content of chicken eggs comprises the steps of: (a) obtaining a grain based chicken feed; (b) forming a mixture of the chicken feed and an oil containing OMEGA-3 polyunsaturated fatty acid such as
39、 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with the oil being from about 3.0 percent to about 10.0 percent by weight of the mixture; (c) thereafter feeding chicken laying hens the mixture as a primary source of food for the hens; and (d) collecting the eggs of such hens laid subsequ
40、ent to the hens eating the mixture. The oil is fish oil, and fish oil may be deodorized. Said hen eggs contain low cholesterol content, which can be fed to humans with the result that serum cholesterol, serum triglycerides, very low density lipoprotein and blood pressure are reduced as compared to h
41、umans eating a like number of regular eggs with a subsequent decrease in heart disease for example coronary heart disease.,Sample 3,ITC: NTU (NEW THERAPEUTIC USE) PN: US5776463 Abstract: Oral pharmaceutical composition contains petals of borage (Boraginacae, Borago officinalis) or extract of borage
42、petals, wherein the extract is freeze-dried soluble extracts of borage petals, and is obtained by extracting with solvent selected from acetone, methyl ethyl ketone and diethyl ketone. The composition is used for reducing heart rate and blood pressure due to stress, prevention and treatment of circu
43、latory heart diseases such as angina, palpitations and hypertension as well as symptoms such as chest pains traveling down to the shoulders and arms, shortness of breath, numbness in fingers, irregular heart beats, arrhythmia, anxiety. The composition can be made into capsule, film-coated tablet, or
44、al drops, tea composition.,Sample 4,ITC: PHY (PHYSICAL PROCESS) PN:US5368874 Abstract: A method for manufacturing intermediate products for preparation of animal feeds. The process comprising the steps of reducing the crude raw material (soya beans, fodder beans, cereals, peas, rape seed and broad b
45、eans) in size, heating a crude granular raw material in a vessel containing a heating device at a temperature of 100 which is sufficient to toast the raw material, feeding the toasted crude raw material from the vessel to a container, cooling the toasted raw material within the container by contacti
46、ng the toasted raw material with cold air (10-30) in counterflow to the feeding of the toasted raw material in order to heat and moisten the cold air and to cool and dry the raw material so as to obtain the intermediate products, feeding the heated moist air back to the vessel thereby recovering the
47、 energy from the heating step. In this method, energy and moisture from the heating process can be recovered and re-used. The method eliminates the anti-nutritional factors in the raw materials of animal feeds and improves the nutritional value of the raw materials.,Sample 5,ITC: ANA (ANALYTIC PROCE
48、SS ); FOR PN:US6759517 Abstract: An allergenic protein from natural rubber latex is provided. The allergenic protein is from the latex or tissue of rubber tree, Hevea brasiliensis. It is oligomeric of monomeric polypeptides. The allergenic protein can be used in assays for identifying and/or quantit
49、ating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex, and can be use in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex. Said allergens can be used as de-sensitizing agents in the tre
50、atment of latex protein allergy.,Sample 6,ITC:BIO (BIOLOGICAL PROCESS ) PN:US20040241784 Abstract: A method for selecting non-pathogenic Gram-positive lactic acid bacteria (Lactobacilli) strains which can combat infections via tissue adherence by a pathogenic Gram-negative or Gram-positive bacteria
51、strains, such as enteropathogenic bacteria strains of Salmonellas, Helicobacter pylori, Yersinia, and Clostridies, especially ECET/0147: K88ac serotype strain of Escherichia coli; and has the properties of the ability to adhere to tissues of an organ that is likely to be infected, the ability to fix
52、 to one another via mutual adhesion sites, and the ability to fix to the attachment determinants of the pathogenic bacterial strain responsible for the infection. The method comprises insolating a single strain from duodenum of each piglets or sows, culturing, and identifying to obtain strains of La
53、ctobacillus and Leuconostoc; treating duodenum of a host (an animal, such as a fowl, a pig, a bovine, a dog, a cat, a horse, an ovine, a caprine or a fish, preferably a piglet) with the Krebs buffer and a glycerolized buffer sequentially to obtain enterocytes and mucous membrane, suspending in buffe
54、r, adding the lactic acid bacteria strains suspension, and stirring to displaying tissue adherence properties on the mucous membrane and on the enterocytes of the duodenum; mixing lactic acid bacteria strains suspension with the pathogenic bacteria suspension, and stirring mildly to observe autoaggr
55、egation (adherence between the lactic acid bacteria of a same strain) and coaggregation (adherence between the lactic acid bacteria and the pathogenic bacteria) properties; and measuring the specificity of the adherence of the lactic acid bacteria to pathogenic bacteria expressing K88 fimbriae. The bacteria strains selected with this method can be mixed with a pharmaceutically acceptable vehicle to prevent or treat infection of a host digestive tract by pathogenic bacterial strains.,
