1、1,AUDGPI Research Collaboration Meeting: Programme Grants,Tuesday February 6th, 2007Andrew W Murphy Department of General Practice, NUI, Galway,2,Format,3,Objectives,To outline experience of SPHERE programme grantTo stimulate discussion regarding 2007 programme grant applications potential topics po
2、tential partners,4,The SPHERE Study,Randomised controlled trial of an intervention for primary care to increase secondary prevention of coronary heart disease M Byrne, M Cupples, AW Murphy, S Smith,5,The SPHERE Study,RCT of a behavioural intervention for primary care, to improve secondary prevention
3、 of coronary heart disease (CHD) Baseline Irish data indicated room for improvement (Byrne & Murphy, 2002)Recent review of trials optimal intervention still elusive (McAlister, 2001),6,Programme objectives,Primary To design, implement and evaluate a multi-faceted intervention to improve both the pro
4、cess of care and objective clinical outcomes for patients with established ischaemic heart disease in general practice.Secondary To perform a qualitative analysis of the development and delivery of the intervention. To perform a health economic analysis of the intervention in the Republic of Ireland
5、 and Northern Ireland. To perform a policy analysis of the context within which the intervention is delivered in the Republic of Ireland and Northern Ireland.,7,Developing RCTs of complex interventions,Campbell et al. BMJ 2000; 321(7262):694-6.,8,a,b,c,f,g,d,e,h,a,b,c,SPHERE Graphical depiction Pere
6、ra BMJ 334:127,9,Reflections on SPHERE programme grant,10,Workload,11,Quality and range of staff,12,Staff turnover,13,Publications,Corrigan M, Cupples ME, Smith SM, Byrne M, Leathem C, Clerkin P, Murphy AW. The contribution of qualitative research in designing a complex intervention for secondary pr
7、evention of coronary heart disease in two different healthcare systems. BMC Health Services Research 2006; 6:90 Byrne M, Cupples ME, Smith SM, Leathem C, Corrigan M, Byrne MC, Murphy AW. Development of a complex intervention for secondary prevention of coronary heart disease in primary care using th
8、e UK Medical Research Council framework. Am Journal of Managed Care2006;12:261-266 Murphy AW, Cupples ME, Smith S, Byrne M, Leathem C, Byrne MC. The SPHERE Study. Secondary prevention of heart disease in general practice: protocol of a randomised controlled trial of tailored practice and patient car
9、e plans with parallel qualitative, economic and policy analyses. ISRCTN24081411. Current Controlled Trials in Cardiovascular Medicine 2005. Jul 29;6(1):11 Byrne M, Corrigan M, Cupples ME, Smith SM, Leathem C, Murphy AW. The SPHERE study: Using psychological theory to inform the development of behavi
10、our change training for primary care staff to increase secondary prevention of coronary heart disease. Irish Journal of Psychology 2005; 26(1-2):53-64.,14,Publications: indirect,Murphy AW, Esterman A, Pilotto L. Cluster randomised controlled trials in primary care: an introduction. EJGP 12(2): 70-73
11、, 2006. Pirkis JE, Blashki GA, Murphy AW, Richards JC, Hickie IB, Ciechomski L. The contribution of general practice based research in the development of national policy: case studies from Ireland and Australia. Australia and New Zealand Health Policy 2006; 3:4. Byrne M, Murphy AW, Walsh J, Shryane
12、E, McGroarty M, Kelleher CC. A cross sectional study of secondary cardiac care in general practice: Impact of personal and practice characteristics. Fam Prac 2006; 23: 295-302 Ononeze V, Murphy AW, Byrne M, Bradley C, MacFarlane A. Patients and health professionals perspectives on the sociocultural
13、influences on secondary cardiac behaviour: a qualitative study of the implications in policy and practice. Fam Prac 23: 587 596, 2006,15,Further reflections,Lancet protocol acceptedZero use of Masters/ PhDsProbably the most rewarding and enjoyable collaborative academic exercise I have been involved
14、 inExplicit strategic 07 departmental goal,16,Objectives,To outline experience of SPHERE programme grantTo stimulate discussion regarding 2007 programme grant applications potential topics potential partners,17,HRB grants,Translational research 1.5 million over five yearsHealth services R Closing da
15、te 07 (EoI) To be confirmed,18,Health services R&D,Support research which is related to the day-to-day practice of health service staff and is capable of showing a demonstrable impact on the health or health care of users of the service. Funded research projects are likely to fall into the areas of
16、health service and systems research and public health research, although other areas are not excluded from the programme. Research proposals should use quantitative or qualitative methods to: study the provision and use of services; evaluate the effectiveness and cost effectiveness of interventions;
17、 examine the resource utilisation of alternative means for healthcare delivery; formally scrutinise innovations and developments;,19,Health services R&D, not,This programme will not fund: laboratory-based research or basic science research, including research based on animals proposals which are sol
18、ely service developments: although the programme will fund research aimed at evaluating the effectiveness of a service or intervention it will not fund the costs of providing the service or intervention itself proposals which are solely: literature reviews, audit, surveys, needs assessment, technolo
19、gy development (although these elements may be part of an integrated research study),20,Funded examples,Susan Smith: Diabetes and peer support?,21,Translational research,is defined as research that applies ideas, insights and discoveries generated through basic scientific inquiry to the treatment or
20、 prevention of human disease. The purpose of these awards is to support the development of clinical research improve outcomes for patients by establishing and supporting teams working full time on extensive research programmes with clear link to patients contribute to the creation of intellectual pr
21、operty and the development of bio-industry by using scientific or technical knowledge to produce new or substantially improved materials, devices, products or services.,22,Funded examples,Reducing hospital infections caused by methicillin-resistant Staphylococcus aureus and vancomycin-resistant ente
22、rococci by effective environmental decontamination and effective hand hygiene Neurocardiovascular influences on cognitive functioning: basic and clinical mechanisms,23,Discussion,Potential topics What, if any, areas have you ambitions for in 2007 ? NUI, Galway: eGFRPotential partners Whom, if anybody, would you like to work with ? In and out of primary care ?,24,Kaplan-Meier risk of CVS composite end point according to baseline eGFR, Glynn07,
