Chapter 15 Leukocyte Migration and Inflammation.ppt
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1、Chapter 15 Leukocyte Migration and Inflammation,The IS relies upon the continual circulation of leukocytes through the body For the Innate IR a variety of lymphocytes, granulocytes, and monocytes can respondFor the Adaptive IR lymphocytes must contact Ag in either tissue, lymph, or blood,Lymphocyte
2、re-circulation,Lymphocytes constantly re-circulate from blood to spleen, lymph nodes, and 3 lymphoid tissues Continual circulation provides systemic protection A complete circuit can be performed 1-2X per day 1 in 105 lymphocytes can recognize a specific Agtherefore, constant circulation increases c
3、hance of lympho contacting Ag,How do leukocytes transit the bloodstream?,They must bind to an endothelial cell first!Endothelial cells exhibit cell adhesion molecules CAMsLymphos, granulos, and monos form receptors which bind to CAMs,The four types of CAMs,Selectins resp. for intial contact between
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