1、Antimalarial, Antiprotozoal, and Antihelmintic Agents,Protozoal Infections,Parasitic protozoa: live in or on humans malaria leishmaniasis amebiasis giardiasis trichomoniasis,Malaria,Caused by the plasmodium protozoa. Four different plasmodium species. Cause: the bite of an infected adult mosquito. C
2、an also be transmitted by infected individuals via blood transfusion, congenitally, or via infected needles by drug abusers.,Malarial Parasite (plasmodium),Two Interdependent Life Cycles Sexual cycle: in the mosquito Asexual cycle: in the human Knowledge of the life cycles is essential in understand
3、ing antimalarial drug treatment. Drugs are only effective during the asexual cycle.,Plasmodium Life Cycle,Asexual cycle: two phases Exoerythrocytic phase: occurs “outside” the erythrocyte Erythrocytic phase: occurs “inside” the erythrocyte Erythrocytes = RBCs,Antimalarial Agents,Attack the parasite
4、during the asexual phase, when it is vulnerable Erythrocytic phase drugs: chloroquine, hydroxychloroquine, quinine, mefloquine Exoerythrocytic phase drug: primaquine May be used together for synergistic or additive killing power.,Antimalarials: Mechanism of Action,4-aminoquinoline derivatives chloro
5、quine and hydroxychloroquine Bind to parasite nucleoproteins and interfere with protein synthesis. Prevent vital parasite-sustaining substances from being formed. Alter pH within the parasite. Interfere with parasites ability to metabolize and use erythrocyte hemoglobin. Effective only during the er
6、ythrocytic phase,Antimalarials: Mechanism of Action,4-aminoquinoline derivatives quinine and mefloquine Alter pH within the parasite. Interfere with parasites ability to metabolize and use erythrocyte hemoglobin. Effective only during the erythrocytic phase.,Antimalarials: Mechanism of Action,diamin
7、ophyrimidines pyrimethamine and trimethoprim Inhibit dihydrofolate reductase in the parasite. This enzyme is needed by the parasite to make essential substances. Also blocks the synthesis of tetrahydrofolate. These agents may be used with sulfadoxine or dapsone for synergistic effects.,Antimalarials
8、: Mechanism of Action,primaquine Only exoerythrocytic drug. Binds and alters DNA. sulfonamides, tetracyclines, clindamycin Used in combination with antimalarials to increase protozoacidal effects,Antimalarials: Drug Effects,Kill parasitic organisms. Chloroquine and hydroxychloroquine also have antii
9、nflammatory effects.,Antimalarials: Therapeutic Uses,Used to kill plasmodium organisms, the parasites that cause malaria. The drugs have varying effectiveness on the different malaria organisms. Some agents are used for prophylaxis against malaria. Chloroquine is also used for rheumatoid arthritis a
10、nd lupus.,Antimalarials: Side Effects,Many side effects for the various agents Primarily gastrointestinal: nausea, vomiting, diarrhea, anorexia, and abdominal pain,Antiprotozoals,atovaquone (Mepron) metronidazole (Flagyl) pentamidine (Pentam) iodoquinol (Yodoxin, Di-Quinol) paromomycin (Humatin),Pro
11、tozoal Infections,amebiasis giardiasis pneumocystosis toxoplasmosis trichomoniasis,Protozoal Infections,Transmission Person-to-person Ingestion of contaminated water or food Direct contact with the parasite Insect bite (mosquito or tick),Antiprotozoals: Mechanism of Action and Uses atovaquone (Mepro
12、n),Protozoal energy comes from the mitochondria Atovaquone: selective inhibition of mitochondrial electron transport Result: no energy, leading to cellular deathUsed to treat mild to moderate P. carinii,Antiprotozoals: Mechanism of Action and Uses metronidazole,Disruption of DNA synthesis as well as
13、 nucleic acid synthesis Bactericidal, amebicidal, trichomonacidalUsed for treatment of trichomoniasis, amebiasis, giardiasis, anaerobic infections, and antibiotic-associated pseudomembranous colitis,Antiprotozoals: Mechanism of Action and Uses pentamidine,Inhibits DNA and RNA Binds to and aggregates
14、 ribosomes Directly lethal to Pneumocystis carinii Inhibits glucose metabolism, protein and RNA synthesis, and intracellular amino acid transportMainly used to treat P. carinii pneumonia and other protozoal infections,Antiprotozoals: Mechanism of Action and Uses iodoquinol (Yodoxin, Di-Quinol),“Lumi
15、nal” or “contact” amebicide Acts primarily in the intestinal lumen of the infected host Directly kills the protozoaUsed to treat intestinal amebiasis,Antiprotozoals: Mechanism of Action and Uses paromomycin,“Luminal” or “contact” amebicide Kills by inhibiting protein synthesisUsed to treat amebiasis
16、 and intestinal protozoal infections, and also adjunct therapy in management of hepatic coma,Antiprotozoals: Side Effects,atovaquone nausea, vomiting, diarrhea, anorexia metronidazole metallic taste, nausea, vomiting, diarrhea, abdominal cramps iodoquinol nausea, vomiting, diarrhea, anorexia, agranu
17、locytosis,Antiprotozoals: Side Effects,pentamidine bronchospasms, leukopenia, thrombocytopenia, acute pancreatitis, acute renal failure, increased liver function studies paromomycin nausea, vomiting, diarrhea, stomach cramps,Antihelmintics,diethylcarbamazine (Hetrazan) mebendazole (Vermox) niclosami
18、de (Niclocide) oxamniquine (Vansil) piperazine (Vermizine) praziquantel (Biltricide) pyrantel (Antiminth) thiabendazole (Mintezol),Antihelmintics,Drugs used to treat parasitic worm infections: helmintic infections Unlike protozoa, helminths are large and have complex cellular structures Drug treatme
19、nt is very specific,Antihelmintics,It is VERY IMPORTANT to identify the causative worm Done by finding the parasite ova or larvae in feces, urine, blood, sputum, or tissue cestodes (tapeworms) nematodes (roundworms) trematodes (flukes),Antihelmintics: Mechanism of Action and Uses,diethylcarbamazine
20、(Hetrazan) Inhibits rate of embryogenesis thiabendazole (Mintezol) Inhibits the helminth-specific enzyme, fumarate reductaseBoth used for nematodes (tissue and some roundworms),Antihelmintics: Mechanism of Action,piperazine (Vermizine) and pyrantel (Antiminth) Blocks acetylcholine at the neuromuscul
21、ar junction, resulting in paralysis of the worms, which are then expelled through the GI tractUsed to treat nematodes (giant worm and pinworm),Antihelmintics: Mechanism of Action,mebendazole (Vermox) Inhibits uptake of glucose and other nutrients, leading to autolysis and death of the parasitic worm
22、Used to treat cestodes and nematodes,Antihelmintics: Mechanism of Action,niclosamide (Niclocide) Causes the worm to become dislodged from the GI wall They are then digested in the intestines and expelledUsed to treat cestodes,Antihelmintics: Mechanism of Action,oxamniquine (Vansil) and praziquantel
23、(Biltricide) Cause paralysis of worms musculature and immobilization of their suckers Cause worms to dislodge from mesenteric veins to the liver, then killed by host tissue reactionsUsed to treat trematodes, cestodes (praziquantel only),Antihelmintics: Side Effects,niclosamide, oxamniquine, praziqua
24、ntel, thiabendazole, piperazine, pyrantel nausea, vomiting, diarrhea, dizziness, headache mebendazole diarrhea, abdominal pain, tissue necrosis,Antimalarial, Antiprotozoal, Antihelmintic Agents: Nursing Implications,Before beginning therapy, perform a thorough health history and medication history,
25、and assess for allergies. Check baseline VS. Check for conditions that may contraindicate use, and for potential drug interactions.,Antimalarial, Antiprotozoal, Antihelmintic Agents: Nursing Implications,Some agents may cause the urine to have an asparagus-like odor, or cause an unusual skin odor, o
26、r a metallic taste; be sure to warn the patient ahead of time. Administer ALL agents as ordered and for the prescribed length of time. Most agents should be taken with food to reduce GI upset.,Antimalarial Agents: Nursing Implications,Assess for presence of malarial symptoms. When used for prophylax
27、is, these agents should be started 2 weeks before potential exposure to malaria, and for 8 weeks after leaving the area. Medications are taken weekly, with 8 ounces of water.,Antimalarial Agents: Nursing Implications,Instruct patient to notify physician immediately if ringing in the ears, hearing de
28、crease, visual difficulties, nausea, vomiting, profuse diarrhea, or abdominal pain occur. Alert patients to the possible recurrence of the symptoms of malaria so that they will know to seek immediate treatment.,Antimalarial, Antiprotozoal, Antihelmintic Agents: Nursing Implications,Monitor for side effects: Ensure that patients know the side effects that should be reported. Monitor for therapeutic effects and adverse effects with long-term therapy.,
