1、A preliminary model for the role of the basal ganglia in natural motor control and motor programming,MURI Meeting, June 4th, 2002 Steve Massaquoi, Zhi-Hong Mao, Eugene Lim, Munther Dahleh, and Eric Feron Massachusetts Institute of Technology,Modeling the lower (motor) loop of the basal ganglia in mo
2、vement,Our model produced reasonable representations of normal and abnormal basal ganglionic functions in lower loop Cruise movement generation Dysfunctions in Parkinsons disease and dystonia,Proposed role of the basal ganglia in regulating cruise movement velocity,Model simulator structure,Dysfunct
3、ion of the basal ganglia in Parkinsons disease,Signs of Parkinsons disease Tremor at rest Slowness of movement (bradykinesia) Rigidity of body,Model simulator structure,Dysfunction of the basal ganglia in dystonia,Signs of dystonia Abnormal posture and tremor,Model simulator structure,Modeling the l
4、ower (motor) loop of the basal ganglia in movement,Our model produced reasonable representations of normal and abnormal basal ganglionic functions in lower loop Cruise movement generation Dysfunctions in Parkinsons disease and dystonia,Role of the higher (cognitive) loop of the basal ganglia in prog
5、rammed behavioral tasks,Conflict resolution over access to limited cognitive resources Switching, brain states transition, and sequence generation Circuit in higher loop is the same as in lower loop A toy example,Conclusions and future work,Conclusions The model is very simple The model is consisten
6、t with the neuronal anatomy of the basal ganglia The same circuit in the model is able to control cruise movement, to reproduce signs in the Parkinsons disease and dystonia, and to execute programmed behavioral tasks Future work Self tuning (learning) through reinforcement Learning cooperative behavior,
